INT316546

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.55 Pain Relevance 0.54

extracellular space (GH1, SST) extracellular region (GH1, SST) cell-cell signaling (SST)

Anatomy Link Frequency hepatocytes 1 GH1 (Homo sapiens) SST (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 36 100.00 Dopamine 44 91.44 agonist 42 90.72 metalloproteinase 1 76.88 Bioavailability 1 65.40 Onset of action 3 57.88 withdrawal 8 5.00 headache 5 5.00 antagonist 3 5.00 tolerance 3 5.00

Disease Link Frequency Relevance Heat Cancer 78 99.68 Adenoma 18 89.44 Acromegaly 36 81.16 Pituitary Cancer 59 80.56 Disease 59 62.20 Hypopituitarism 3 58.92 Prolactinoma 47 50.00 Thyroid Neoplasm 1 16.92 Galactorrhea 10 5.00 Recurrence 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

More recently, it has been suggested that a sst ligand may also act peripherally on the GH/IGF-1 axis by binding to somatostatin receptors on peripheral organs, such as hepatocytes in the liver, to inhibit the secretion of IGF-1 [92].

GH Binding (binding) of somatostatin in hepatocytes associated with somatostatin

1) Confidence 0.03 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 0.45 Pain Relevance 0.37

GH secretion is regulated through ligand binding of somatostatin to both sst2 and sst5, whereas SSA binds preferentially sst2 [26].

GH Binding (binding) of sst2 associated with somatostatin

2) Confidence 0.01 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.10 Pain Relevance 0.17

General Comments

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