INT317255

Context Info Confidence 0.49 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.05

extracellular space (Pyy, Npy) extracellular region (Pyy, Npy)

Pyy (Mus musculus) Npy (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 13 94.72 Neurotransmitter 1 48.84 Neuropeptide 1 47.16 agonist 18 5.00 tolerance 16 5.00 qutenza 2 5.00 Potency 2 5.00 tetrodotoxin 1 5.00 member 8 1 5.00 nerve block 1 5.00

Disease Link Frequency Relevance Heat Impaired Glucose Tolerance 16 5.00 Targeted Disruption 7 5.00 Diabetes Mellitus 2 5.00 Constipation 2 5.00 Stress 2 5.00 Body Weight 1 5.00 Obesity 1 5.00 Weight Gain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Anatomical and functional studies have shown that Y1 receptors are targeted to basolateral epithelial membranes (Mannon et al., 1999; Cox and Tough, 2002) and would therefore be activated by endogenous PYY or NPY released into the subepithelial area.

PYY Positive_regulation (activated) of Localization (released) of NPY

1) Confidence 0.49 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0 Pain Relevance 0.05

General Comments

This test has worked.