INT317307

Context Info Confidence 0.12 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.56 Pain Relevance 0

cytosol (Hsp90aa1, Pink1) response to stress (Hsp90aa1, Pink1) cytoplasm (Hsp90aa1, Pink1) unfolded protein binding (Hsp90aa1) protein folding (Hsp90aa1) mitochondrion (Pink1)

Hsp90aa1 (Mus musculus) Pink1 (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 11 5.00 Central nervous system 3 5.00 midbrain 2 5.00 Catecholamine 2 5.00 Glutamate 2 5.00 Locus ceruleus 1 5.00 gABA 1 5.00 monoamine 1 5.00 Substantia nigra 1 5.00 Eae 1 5.00

Disease Link Frequency Relevance Heat Death 14 99.92 Disease 88 97.64 Toxicity 7 72.44 Neurodegenerative Disease 4 41.44 Parkinson's Disease 49 39.44 Stress 17 29.36 Aging 2 25.84 Apoptosis 7 5.00 Targeted Disruption 6 5.00 Drug Induced Neurotoxicity 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PINK1 interacts with several chaperons, like Hsp90 and Cdc37, and loss of this interaction can contribute to PD pathogenesis (Moriwaki et al., 2008).

Hsp90 Binding (interacts) of PINK1 associated with disease

1) Confidence 0.12 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.56 Pain Relevance 0

General Comments

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