INT317560

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pdpk1, Pik3r1) cytosol (Pdpk1, Pik3r1) signal transduction (Pdpk1, Pik3r1)
plasma membrane (Pdpk1, Pik3r1) kinase activity (Pdpk1, Pik3r1) intracellular (Pik3r1)
Pdpk1 (Mus musculus)
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 39 96.84 Very High Very High Very High
agonist 1 80.32 Quite High
Morphine 77 76.60 Quite High
tolerance 28 71.36 Quite High
Delta opioid receptors 1 66.96 Quite High
antagonist 8 65.92 Quite High
analgesia 4 64.84 Quite High
opioid receptor 84 50.76 Quite High
Opioid 14 50.00 Quite Low
Antinociceptive 3 41.64 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 18 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDK1 is recruited to the membrane by PI3K-generated PIP3 (5) where it phosphorylates and activates AGC kinases, such as PKC and Akt, through phosphorylation of Akt Thr308 (6).
PDK1 Binding (recruited) of PI3K associated with kinase c
1) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.65

General Comments

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