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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Car2, Camk2a) cytosol (Car2) extracellular space (Car2)
lyase activity (Car2) plasma membrane (Camk2a) kinase activity (Camk2a)
Anatomy Link Frequency
cardiomyocyte 1
Car2 (Mus musculus)
Camk2a (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 1 94.00 High High
nMDA receptor 1 91.96 High High
opioid receptor 84 90.72 High High
Glutamate 10 86.72 High High
Kinase C 39 74.04 Quite High
Opioid 14 50.00 Quite Low
Morphine 77 46.56 Quite Low
agonist 3 24.64 Low Low
tolerance 28 15.68 Low Low
Delta opioid receptors 1 11.28 Low Low
Disease Link Frequency Relevance Heat
Hypertrophy 4 99.82 Very High Very High Very High
Coronary Heart Disease 13 92.36 High High
Body Weight 5 81.00 Quite High
Pressure And Volume Under Development 3 64.20 Quite High
Natriuresis 5 50.00 Quite Low
Urological Neuroanatomy 18 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low
Hypertension 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because increases in cytoplasmic Ca2+ can induce cardiomyocyte hypertrophy through Ca2+/calmodulin-mediated activation of CaMKII signalling [30], we assessed the activity of this pathway.
Ca2 Positive_regulation (activation) of CaMKII in cardiomyocyte associated with hypertrophy
1) Confidence 0.19 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.58 Pain Relevance 0
Ca2+-CaM then increases and activates CaMKII (13) that, in turn, acts on nNOS Ser847 to reduce Ca2+-CaM binding and NO production (14).
Ca2 Positive_regulation (increases) of CaMKII
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.32

General Comments

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