INT31759

From wiki-pain
Revision as of 22:46, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.33
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
endothelial cells 2
cortex 2
Egf (Mus musculus)
Pain Link Frequency Relevance Heat
Taxol 7 97.80 Very High Very High Very High
psoriasis 3 93.16 High High
abdominal pain 1 89.76 High High
monoamine 13 87.68 High High
cytokine 9 82.40 Quite High
Somatostatin 3 77.52 Quite High
Inflammation 42 69.24 Quite High
Pain 3 50.00 Quite Low
interstitial cystitis 2 50.00 Quite Low
nMDA receptor 4 30.96 Quite Low
Disease Link Frequency Relevance Heat
Cancer 10 99.84 Very High Very High Very High
Cicatrix 126 99.12 Very High Very High Very High
Wound Healing 51 98.30 Very High Very High Very High
Targeted Disruption 110 97.04 Very High Very High Very High
Arthropathy 4 96.64 Very High Very High Very High
Diabetic Foot Ulcer 2 96.04 Very High Very High Very High
Injury 104 95.12 Very High Very High Very High
Psoriasis 3 93.16 High High
Ulcers 33 92.40 High High
Abdominal Pain 1 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with PKI 166 also decreased the expression of phosphorylated EGF-R by tumor cells and tumor-associated endothelial cells, and this was even more pronounced with PKI 166 plus Taxol treatment.
Negative_regulation (decreased) of Gene_expression (expression) of EGF-R in endothelial cells associated with cancer and taxol
1) Confidence 0.53 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12782601 Disease Relevance 1.20 Pain Relevance 0.29
Special attention was focused when a study by Pedal et al. (10) showed that EGF was involved in scarless wound healing in which increased expression of EGF in the early murine fetal period was found and decreased EGF expression was noted during the scar formation at late pregnancy.
Negative_regulation (decreased) of Gene_expression (expression) of EGF associated with cicatrix and wound healing
2) Confidence 0.41 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 1.32 Pain Relevance 0.11
Since 1983, recombinant human EGF (rh-EGF) has been produced in large quantities by the recombination of the human EGF gene and expression in microorganisms.
Negative_regulation (recombination) of Gene_expression (expression) of EGF gene
3) Confidence 0.41 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 1.03 Pain Relevance 0
Compared to the ulcerated untreated mice, those treated with PK for 3 days showed decreased the levels of thiobarbituric acid reactive substances (TBARS) (32.7%, P < 0.05) and protein carbonyl (37.7%, P < 0.001), and increased mucin (42.2%, P < 0.01), mucosal PGE2 (21.4%, P < 0.05), and expressions of COX-1 and 2 (26.9% and 18.5%, P < 0.05), EGF (149.0%, P < 0.001) and VEGF (56.9%, P < 0.01).
Negative_regulation (decreased) of Gene_expression (expressions) of EGF
4) Confidence 0.41 Published 2008 Journal BMC Complement Altern Med Section Abstract Doc Link PMC2266895 Disease Relevance 0.15 Pain Relevance 0
Despite these equivalent levels of EGF receptor expression, p-EGF receptor protein was significantly decreased in the prefrontal cortex of HB-EGF KO mice (P<0.05 vs. control mice) (Fig. 6c).
Negative_regulation (levels) of Gene_expression (expression) of EGF in cortex associated with targeted disruption
5) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.71 Pain Relevance 0.04
Circadian levels of GH and EGF, normal before therapy, were significantly decreased after therapy.
Negative_regulation (decreased) of Gene_expression (levels) of EGF
6) Confidence 0.18 Published 1988 Journal Arch. Dermatol. Res. Section Abstract Doc Link 2900624 Disease Relevance 0.88 Pain Relevance 0.32
CONCLUSIONS: Treatment of PBS/IC patients with CyA resulted in significantly decreased urinary levels of EGF.
Negative_regulation (decreased) of Gene_expression (levels) of EGF
7) Confidence 0.10 Published 2008 Journal Urology Section Body Doc Link 18387391 Disease Relevance 0.05 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox