INT317979

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.63
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
livers 2
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 43 99.30 Very High Very High Very High
metalloproteinase 53 88.08 High High
Inflammation 60 87.64 High High
cytokine 7 81.12 Quite High
Inflammatory response 5 68.96 Quite High
fibrosis 40 60.84 Quite High
rheumatoid arthritis 1 50.16 Quite High
cva 1 42.88 Quite Low
Angina 2 30.76 Quite Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 39 100.00 Very High Very High Very High
Fibrosis 53 99.64 Very High Very High Very High
Chronic Hepatitis 1 99.08 Very High Very High Very High
Hepatitis Virus Infection 1 97.76 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 1 96.68 Very High Very High Very High
Cirrhosis 18 96.44 Very High Very High Very High
Liver Disease 9 93.00 High High
Hepatocellular Cancer 59 92.12 High High
Autoimmune Disease 19 91.64 High High
INFLAMMATION 62 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Palliative resection enhances MMP2 activity, elevates tumor protein levels of MMP2 and VEGF, and down-regulates TIMP2 in situ
Positive_regulation (elevates) of Transcription (levels) of MMP2 associated with cancer and palliative
1) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.60 Pain Relevance 0.59
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Positive_regulation (upregulated) of Transcription (expression) of MMP-2 associated with fibrosis
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
Our data show a strong upregulation of the mRNA expression of collagenase (MMP1) and both gelatinases (MMP2 and MMP9) compared with controls.
Positive_regulation (upregulation) of Transcription (expression) of MMP2
3) Confidence 0.34 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.38 Pain Relevance 0.19
Similarly, increased mRNA levels of MMP-9 or MMP-2 have been found in the livers of patients with chronic viral hepatitis as well as nonalcoholic steatohepatitis [104].
Positive_regulation (increased) of Transcription (levels) of MMP-2 in livers associated with nash(non-alcoholic steatohepatitis) and hepatitis virus infection
4) Confidence 0.12 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.32 Pain Relevance 0.53

General Comments

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