INT318221

Context Info Confidence 0.41 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.63 Pain Relevance 0

nucleoplasm (SIRT1, FOXO3) cytoplasm (SIRT1, FOXO3) nucleus (SIRT1, FOXO3) cell differentiation (SIRT1) mitochondrion (SIRT1) nuclear envelope (SIRT1)

SIRT1 (Homo sapiens) FOXO3 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 6 5.00 Analgesic 2 5.00 cINOD 2 5.00 Glutamate 2 5.00

Disease Link Frequency Relevance Heat Stress 20 93.48 Aging 4 89.24 Apoptosis 62 69.76 Necrosis 2 57.36 Fever 2 23.56 Lymphopenia 2 5.00 Death 2 5.00 Metabolic Disorder 2 5.00 Hypersensitivity 2 5.00 Cardiovascular Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, Northern blot analysis showed that RNA levels of the SIRT1-dependent transcription factor FOXO3A and its target GADD45 were increased in the studied group after marathon (Figure 7).

SIRT1 Positive_regulation (dependent) of FOXO3A

1) Confidence 0.41 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.12 Pain Relevance 0

SIRT1 increased FOXO3A ability to induce cell cycle arrest and enhanced expression of a FOXO3A target involved in DNA repair, such as GADD45 [24].

SIRT1 Positive_regulation (increased) of FOXO3A

2) Confidence 0.41 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.50 Pain Relevance 0

General Comments

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