INT318236

Context Info Confidence 0.42 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.59 Pain Relevance 0.05

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1) nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)

SIRT1 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 5 90.64 Central nervous system 1 5.00 Analgesic 1 5.00 anesthesia 1 5.00 cINOD 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 31 99.82 Shock 2 77.44 Aging 66 69.36 Stress 36 57.84 Sprains And Strains 14 37.80 Starvation 23 5.00 Coma 22 5.00 Disease 3 5.00 Adhesions 2 5.00 Cardiovascular Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data suggest that the physiological load imposed in amateur runners during marathon attenuates the extent of apoptosis and may interfere with sirtuin expression.

Spec (may) Negative_regulation (interfere) of Gene_expression (expression) of sirtuin associated with apoptosis

1) Confidence 0.42 Published 2010 Journal BMC Physiol Section Abstract Doc Link PMC2893521 Disease Relevance 0.45 Pain Relevance 0

The expression of Sirt2, a member of the Drosophila Sirtuin family [95], was strongly decreased in the mub, BG00817 and esg mutant backgrounds.

Negative_regulation (decreased) of Gene_expression (expression) of Sirtuin

2) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912381 Disease Relevance 0.14 Pain Relevance 0.05

General Comments

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