INT318357

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.26 Pain Relevance 0.20

cytoplasm (Pmp2, Adcy3) lipid binding (Pmp2) transport (Pmp2) lyase activity (Adcy3) plasma membrane (Adcy3) nucleus (Adcy3)

Pmp2 (Mus musculus) Adcy3 (Mus musculus)

Pain Link Frequency Relevance Heat Thalamus 3 75.96 amygdala 4 71.56 Hippocampus 5 70.48 antagonist 13 55.64 alcohol 3 25.20 Neurobehavioral 6 5.00 Eae 6 5.00 anesthesia 5 5.00 ketamine 2 5.00 Versed 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 5 98.28 Cognitive Disorder 9 82.68 Body Weight 13 5.00 Anxiety Disorder 13 5.00 Shock 8 5.00 Post-traumatic Stress Disorder 7 5.00 Weight Gain 2 5.00 Body Weight Changes 1 5.00 Weight Loss 1 5.00 Congenital Anomalies 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because cells dying by apoptosis are no longer AC3 positive approximately 24 hours after drug exposure, the increased AC3 staining in the P2+P7 animals compared to the P7 animals cannot be reflective of damage that is still visible from the P2 exposure.

P2 Binding (staining) of AC3 associated with apoptosis

1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.26 Pain Relevance 0.20

General Comments

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