INT318448

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.31
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
gracilis 2
Mir21 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 256 99.74 Very High Very High Very High
Bioavailability 1 98.24 Very High Very High Very High
chemokine 24 55.92 Quite High
Sciatic nerve 24 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
analgesia 10 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Demyelination 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 256 99.74 Very High Very High Very High
Injury 260 99.24 Very High Very High Very High
Myocardial Infarction 12 98.88 Very High Very High Very High
Cancer 37 93.64 High High
Targeted Disruption 4 91.20 High High
Glioblastoma 2 85.28 High High
Apoptosis 40 82.16 Quite High
Shock 8 76.44 Quite High
Brain Tumor 2 75.84 Quite High
Nerve Compression Syndromes 60 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, adenoviral overexpression of miR-21 had a protective effect on myocardial infarction by decreasing the infarct size by 29% at 24 h [31].
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-21 associated with myocardial infarction
1) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.77 Pain Relevance 0
However, as shown in the Figure 2, in the investigation of minimal ischemic time that would induce the expression of these 3 miRNAs, we had demonstrated that 1 h of ischemia was able to increase the expression of miR-21 and miR-200c and 2 h of ischemia would increase the expression of these three miRNAs, implying the epigenetic regulation could be induced by a shorter time of ischemia before a remarked pathophysiologic change could be observed by a longer time of ischemia.
Positive_regulation (increase) of Gene_expression (expression) of miR-21 associated with ischemia
2) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.88 Pain Relevance 0.35
At 14 d, there was still a 7.5-fold increased expression of miR-21.
Positive_regulation (increased) of Gene_expression (expression) of miR-21
3) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.48 Pain Relevance 0.17
The overexpression of miR-21 has been shown to be in a number of medium-scale and high-scale profiling experiments that were designed for the detection of miRNAs that are dysregulated in cancer [27].
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-21 associated with cancer
4) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 1.17 Pain Relevance 0.11
This study has profiled an increased expression of miR-21, miR-200c, and miR-205 in the gracilis muscle following ischemic injury and identified four potential target genes (Nqo1, Pdpn, CXCL3, and Rad23b) of the miR-21 by using different prediction algorithms and monitoring the expression of miRNA and mRNA at different time point on a genome-wide basis.
Positive_regulation (increased) of Gene_expression (expression) of miR-21 in gracilis associated with injury
5) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.23 Pain Relevance 0.03
Ischemia for only 1 h was sufficient to induce the expression of miR-21 and miR-200c during the reperfusion stage; and 2 h of ischemia were required to induce the expression of miR-205.
Positive_regulation (induce) of Gene_expression (expression) of miR-21 associated with ischemia
6) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.57 Pain Relevance 0.14
Ischemia for only 1 h was sufficient to induce the expression of miR-21 and miR-200c during the reperfusion stage; and 2 h of ischemia were required to induce the expression of miR-205.
Positive_regulation (sufficient) of Gene_expression (expression) of miR-21 associated with ischemia
7) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.57 Pain Relevance 0.14
In contrast, the expression of miR-21 gradually increased to its maximum level at 7 d and persisted throughout the experiment for at least 14 d after the ischemic injury.
Positive_regulation (increased) of Gene_expression (expression) of miR-21 associated with injury
8) Confidence 0.19 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.95 Pain Relevance 0.13
In this study, we had demonstrated an ~6-fold increase in the expression of miR-21 in DRG neurons at 1 week after denervation that lasted for up to 6 months. miR-21 is one of the most prominent miRNAs implicated in human malignancies [36].
Positive_regulation (increase) of Gene_expression (expression) of miR-21 in neurons
9) Confidence 0.14 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.68 Pain Relevance 0
There was a tremendous upregulation of miR-21 expression in basal level controls with resveratrol (up 391.4) and longevinex (760.9) which was lowered considerably in IR (up 61.5 and 59.3). miR-539 is upregulated to high level (214 fold) in IR samples and were further up-regulated in resveratrol preteated samples.
Positive_regulation (upregulation) of Gene_expression (expression) of miR-21
10) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0 Pain Relevance 0.05
We used in situ hybridization to localize miR-21 expression in the DRG sections.
Positive_regulation (localize) of Gene_expression (expression) of miR-21
11) Confidence 0.10 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0 Pain Relevance 0

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