INT318505

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 6.55
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (FPR2) plasma membrane (FPR2) signal transducer activity (FPR2)
Anatomy Link Frequency
blood 4
alveolar macrophages 4
FPR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 140 100.00 Very High Very High Very High
dexamethasone 105 90.88 High High
corticosteroid 155 68.72 Quite High
cytokine 15 57.08 Quite High
agonist 5 24.44 Low Low
Inflammatory response 5 23.60 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
Versed 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 140 100.00 Very High Very High Very High
Asthma 505 99.92 Very High Very High Very High
Occupational Lung Diseases 185 98.84 Very High Very High Very High
Inflammatory Bowel Disease 5 94.08 High High
Pulmonary Disease 10 90.44 High High
Systemic Sclerosis 5 89.92 High High
Hypersensitivity 5 79.76 Quite High
Rhinitis 15 79.40 Quite High
Adhesions 15 77.00 Quite High
Death 5 33.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are in line with the current observation of reduced basal and LPS-stimulated production of LXA4 from alveolar macrophages of patients with severe asthma.
Negative_regulation (reduced) of Gene_expression (production) of LXA4 in alveolar macrophages associated with asthma
1) Confidence 0.54 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.18 Pain Relevance 0
Using a similar method as our study to distinguish severe from non-severe asthma, a deficiency in both baseline and divalent cation ionophore-stimulated production of LXA4 in whole blood of patients with severe asthma compared to moderate asthma was established, while the production of cysteinyl-leukotrienes and LTB4 were increased[9].
Negative_regulation (deficiency) of Gene_expression (production) of LXA4 in blood associated with asthma
2) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.46 Pain Relevance 0.18
The possibility that dysregulation of the balance among these arachidonic acid products might contribute to the persistent inflammation in severe asthma has been supported by the demonstration of an increased generation of cysteinyl-leukotrienes with impaired biosynthesis of lipoxin A4 (LXA4) from whole blood of patients with severe asthma compared to non-severe asthma patients[9].
Negative_regulation (impaired) of Gene_expression (biosynthesis) of lipoxin A4 in blood associated with asthma and inflammation
3) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.31 Pain Relevance 0.31
Generation of LXA4 can decrease and LTB4 increase with age [41,42], but there is no information available at present on the influence of age on the release of these eicosanoids from human alveolar macrophages.
Negative_regulation (decrease) of Gene_expression (Generation) of LXA4 in alveolar macrophages
4) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.14 Pain Relevance 0.28
We have shown that the basal generation of the proinflammatory LTB4 and the anti-inflammatory LXA4 were both lower in cultured AMs from severe asthmatics compared to those from non-asthmatics, while only LXA4 was lower in severe asthmatics compared to non-severe asthmatics.
Negative_regulation (lower) of Gene_expression (generation) of LXA4 associated with inflammation and occupational lung diseases
5) Confidence 0.34 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.45 Pain Relevance 0.30

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