INT319393

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.61 Pain Relevance 0.12

cell adhesion (EMR1) plasma membrane (EMR1) signal transducer activity (EMR1)

Anatomy Link Frequency eosinophil 1 EMR1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 50 99.08 Inflammatory response 4 61.52 chemokine 12 32.36 aspirin 10 5.00 fibrosis 4 5.00 lidocaine 2 5.00 cytokine 2 5.00 cocaine 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 54 99.08 Adhesions 4 98.64 Rhinitis 124 98.56 Asthma 34 91.96 Anaphylaxis 2 87.60 Eczema 62 86.72 Disease 46 81.60 Eosinophilic Esophagitis 10 63.44 Chronic Sinusitis 28 50.00 Nasal Polyps 12 28.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increased transcription of both EMR3 and EMR1 was observed in our exon array data.

Transcription (transcription) of EMR1

1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.91 Pain Relevance 0.08

Whether EMR3 and EMR1 transcription per eosinophil is increased in aCRSwNP or the increased transcription reflects elevated numbers of infiltrating eosinophils is unknown.

Transcription (transcription) of EMR1 in eosinophil

2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.70 Pain Relevance 0.04

General Comments

This test has worked.