INT319434

Context Info Confidence 0.44 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0.13

extracellular space (EMR3) extracellular region (EMR3) plasma membrane (EMR3) signal transducer activity (EMR3)

Anatomy Link Frequency CLC 1 EMR3 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 5 76.40 Inflammation 25 62.00 chemokine 6 5.00 fibrosis 2 5.00 Inflammatory response 2 5.00 lidocaine 1 5.00 cytokine 1 5.00 cocaine 1 5.00

Disease Link Frequency Relevance Heat Chronic Sinusitis 14 96.48 Asthma 17 96.20 Eosinophilic Esophagitis 5 84.76 INFLAMMATION 27 62.00 Rhinitis 62 58.88 Disease 23 48.72 Hypersensitivity 7 40.32 Eczema 31 38.12 Nasal Polyps 6 16.88 Polyps 13 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our qRT-PCR results for CCL13, CCL18, CRISP3, EMR3, and IL1RL1 (ST2) (Figure 2) and the increased presence of CLC (Figure 3) and CCL18 [17] protein in separately collected airway specimens from CRS or asthmatic patients, in accordance with their increased mRNA levels in our aCRSwNP patients, further support the validity of our exon array data.

Localization (presence) of EMR3 in CLC associated with asthma and chronic sinusitis

1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.59 Pain Relevance 0.13

General Comments

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