INT319670

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nfe2l2, Keap1) cytoplasm (Nfe2l2, Keap1) endoplasmic reticulum (Keap1)
plasma membrane (Nfe2l2) DNA binding (Nfe2l2)
Nfe2l2 (Mus musculus)
Keap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 23 99.34 Very High Very High Very High
Chronic Disease 1 90.00 High High
Cancer 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, it has been shown that NRF2 protein levels increase after oxidative stress because its negative regulator, KEAP1, loses its ability to bind NRF2 and cause its proteasome-mediated degradation during oxidative stress.
Negative_regulation (loses) of NRF2 Binding (bind) of KEAP1 associated with stress
1) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2898415 Disease Relevance 0.44 Pain Relevance 0

General Comments

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