INT320723

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.00 Pain Relevance 0.03

cytosol (BRAF) plasma membrane (BRAF) nucleus (BRAF) cytoplasm (BRAF)

BRAF (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 2 59.36 agonist 4 5.00 palliative 1 5.00 cINOD 1 5.00 Inflammatory response 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Microsatellite Instability 8 99.80 Cancer 87 98.80 Melanoma 91 93.20 Chromosome Aberrations 10 89.92 Skin Cancer 62 73.36 Colon Cancer 53 50.00 Isochromosomes 1 49.68 Metastasis 31 35.52 Apoptosis 9 29.96 Hyperplasia 1 17.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mutations of BRAF were shown to be absent in UMs [95, 99].

Negative_regulation (absent) of Gene_expression (Mutations) of BRAF

1) Confidence 0.38 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 0.66 Pain Relevance 0

Loss of heterozygosity, BRAF and KRAS mutations and microsatellite instability analysis

Negative_regulation (Loss) of Gene_expression (mutations) of BRAF associated with microsatellite instability

2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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