INT320730

Context Info Confidence 0.60 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.84 Pain Relevance 0

nucleoplasm (NBN) nucleolus (NBN) chromosome (NBN) nucleus (NBN) intracellular (NBN) cell cycle (NBN)

NBN (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 2 5.00

Disease Link Frequency Relevance Heat Melanoma 182 99.56 Cancer 112 95.72 Disease 8 81.00 Apoptosis 8 62.56 Metastasis 60 58.80 Skin Cancer 124 50.00 Congenital Anomalies 8 26.44 Chromosome Aberrations 20 25.68 Monosomy 40 14.16 Aneuploidy 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The NBS1-gene is found to be overexpressed in 50% of UM [62].

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of NBS1-gene associated with melanoma

1) Confidence 0.60 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 0.93 Pain Relevance 0

It is theorized that overexpressed NBS1 could allow UM progression by promoting the repair of DNA damage which occurs more frequently in advanced tumors with increased genetic instability.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of NBS1 associated with cancer and melanoma

2) Confidence 0.40 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 0.91 Pain Relevance 0

General Comments

This test has worked.