INT320794

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 3.04 Pain Relevance 0.27

cytoplasm (VEGFA, Flt4) extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA) proteinaceous extracellular matrix (VEGFA) plasma membrane (Flt4)

Anatomy Link Frequency vasculature 1 lymphatic vessel 1 VEGFA (Homo sapiens) Flt4 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 8 96.20 antagonist 5 93.60 Kinase C 1 92.88 cytokine 5 88.96 metalloproteinase 1 16.12 Bioavailability 1 7.32 imagery 36 5.00 anesthesia 7 5.00 positron emission tomography 7 5.00 isoflurane 6 5.00

Disease Link Frequency Relevance Heat Organ Transplantation 6 99.72 Cancer 327 96.28 INFLAMMATION 7 96.20 Stomach Cancer 2 87.16 Hematological Disease 2 87.16 Prostate Cancer 2 86.08 Targeted Disruption 7 84.44 Metastasis 131 80.96 Graft Vs Host Disease 1 31.28 Hypoxia 3 27.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

VEGFR3 binds VEGF-C and -D and is directly involved in formation of the lymphatic vasculature physiologic and tumor development [27, 28].

VEGF Binding (binds) of VEGFR3 in vasculature associated with cancer

1) Confidence 0.08 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902148 Disease Relevance 0.49 Pain Relevance 0.05

VEGF-C, a ligand of VEGFR-3, has been shown to be able to induce lymphatic vessel growth in the cornea [9,10].

VEGF Binding (ligand) of VEGFR-3 in lymphatic vessel

2) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.38 Pain Relevance 0.13

On a related note, sVEGFR-3 can not only bind VEGFR-3 but also acts as a trap for VEGF-C, which blocks VEGFR-3 signaling [2,5].

VEGF Binding (trap) of VEGFR-3

3) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.06 Pain Relevance 0.05

On a related note, sVEGFR-3 can not only bind VEGFR-3 but also acts as a trap for VEGF-C, which blocks VEGFR-3 signaling [2,5].

VEGF Binding (trap) of VEGFR-3

4) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.11 Pain Relevance 0.05

General Comments

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