INT320983

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.17 Pain Relevance 0.09

extracellular space (Pth)

Anatomy Link Frequency blood 2 Pth (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 23 86.56 Inflammation 36 83.84 imagery 9 48.16 Crohn's disease 2 17.44 cva 13 5.00 rheumatoid arthritis 8 5.00 corticosteroid 4 5.00 cytokine 4 5.00 tolerance 3 5.00 Sicca syndrome 2 5.00

Disease Link Frequency Relevance Heat Hypercalcemia 10 94.16 Fibrosis 17 86.56 Interstitial Lung Diseases 143 86.04 INFLAMMATION 36 83.84 Hemorrhage 1 78.40 Hypopigmentation 1 78.00 Syndrome 26 70.64 Foreign Bodies 1 62.16 Granuloma 8 53.44 Disease 79 51.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These recommendations are based on the amount of vitamin D that is needed to maximally suppress PTH (1–84) secretion [22], but there is no consensus, as some investigators advocate that the 25(OH)2D level needed to maximally suppress PTH is 30 to 44 ng/mL [23].

Negative_regulation (suppress) of Localization (secretion) of PTH

1) Confidence 0.38 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0 Pain Relevance 0

Loss-of-function mutations in CASR impair the feedback inhibition of parathyroid hormone secretion in response to a rise in the blood calcium concentration.

Negative_regulation (inhibition) of Localization (secretion) of parathyroid hormone in blood

2) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 1.17 Pain Relevance 0.09

General Comments

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