INT32129

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Context Info
Confidence 0.36
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.64
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Esrra) DNA binding (Esrra)
Anatomy Link Frequency
lymph node 1
myometrium 1
liver 1
skin 1
HSF 1
Esrra (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 99.38 Very High Very High Very High
Dismenorea 8 95.36 Very High Very High Very High
depression 1 93.60 High High
withdrawal 3 93.36 High High
anesthesia 3 89.08 High High
imagery 62 88.24 High High
Neuronal excitability 5 76.72 Quite High
gABA 2 75.00 Quite High
cytokine 5 62.64 Quite High
hyperexcitability 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Shock 14 99.40 Very High Very High Very High
INFLAMMATION 8 99.38 Very High Very High Very High
Infection 108 99.22 Very High Very High Very High
Cancer 39 98.74 Very High Very High Very High
Hirsutism 3 98.16 Very High Very High Very High
Frailty 17 98.04 Very High Very High Very High
Aging 3 98.00 Very High Very High Very High
Neurological Disease 2 97.56 Very High Very High Very High
Epilepsy 1 95.76 Very High Very High Very High
Osteoporosis 4 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conditions of changing steroid hormone levels are a particularly vulnerable time for the manifestation of neurological disorders, including catamenial epilepsy, premenstrual syndrome (PMS), and postpartum depression.
Gene_expression (levels) of steroid hormone associated with epilepsy, neurological disease, depression, dismenorea and post-partum depression
1) Confidence 0.36 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19632051 Disease Relevance 0.45 Pain Relevance 0.25
HSPCs function in two major regulatory processes: 1) the heat shock response via HSF [38] and 2) steroid hormone receptor stabilization (reviewed in [39]–[41]).
Gene_expression (stabilization) of steroid hormone receptor in HSF associated with shock
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.26 Pain Relevance 0
In conclusion, our results demonstrate that the development of the inner myometrium is particularly sensitive to oestrogen antagonism, and is affected by steroid receptor modulation.
Gene_expression (modulation) of steroid receptor in myometrium
3) Confidence 0.07 Published 2010 Journal Reproduction Section Abstract Doc Link 20368191 Disease Relevance 0.34 Pain Relevance 0.36
This aging process can be mimicked in animal models such as mice, by gonadectomy, leading to an inhibition of steroid hormone production and decreased bone mass.
Gene_expression (production) of steroid hormone associated with aging
4) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.62 Pain Relevance 0.05
However, virus was recovered from the thymus when the thymocyte number was markedly decreasing at days 3 and 5 post-infection in the lethal infection (Fig. 7B and 7C), suggesting that the steroid hormone synthesized by both virus and host may contribute to thymus atrophy as well as the direct effect of virus infection against thymic cells.
Gene_expression (synthesized) of steroid hormone in thymus associated with frailty and infection
5) Confidence 0.05 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 2.22 Pain Relevance 0.03
The transcripts exclusive to the liver are involved in several functions such as cell defence, protein and steroid hormone synthesis, as well as transport and amino acid metabolism.
Gene_expression (synthesis) of steroid hormone in liver
6) Confidence 0.03 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.15 Pain Relevance 0
No correlation was demonstrated between primary tumor size, lymph node status, percentage of tumor cells, presence of inflammatory cells, histopathologic grade, steroid receptor status, expression of glucose receptors Glut-1 and the uptake of FDG by the primary tumor [39].
Gene_expression (expression) of steroid receptor in lymph node associated with inflammation and cancer
7) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175073 Disease Relevance 1.23 Pain Relevance 0.20
Steroid hormone levels in serum and skin receptor concentrations in hirsutism.
Gene_expression (levels) of Steroid hormone in skin associated with hirsutism
8) Confidence 0.01 Published 1985 Journal Endocrinol. Exp. Section Title Doc Link 2931274 Disease Relevance 0.35 Pain Relevance 0.09

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