INT321893

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DAO) oxidoreductase activity (DAO) plasma membrane (GRIN3B)
peroxisome (DAO) cellular nitrogen compound metabolic process (DAO)
DAO (Homo sapiens)
GRIN3B (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 16 100.00 Very High Very High Very High
Bioavailability 3 85.84 High High
midbrain 1 79.68 Quite High
agonist 9 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 3 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 13 22.88 Low Low
Schizophrenia 22 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Psychosis 3 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
Nephrotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although 3-hydroxyquinolin-2-(1H)-one is a very potent DAAO inhibitor (IC50 = 4nM) it also has weak affinity for the glycine site of the NMDA receptor (29% inhibition at 10µM) and some affinity for DDO (IC50 = 855nM).
DAAO Binding (affinity) of NMDA receptor associated with nmda receptor
1) Confidence 0.03 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0 Pain Relevance 0.19

General Comments

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