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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.57
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR8) RNA binding (TLR8) intracellular (TLR8)
DNA binding (TLR8)
Anatomy Link Frequency
poly 1
monocytes 1
TLR8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 92 97.28 Very High Very High Very High
chemokine 17 90.76 High High
Inflammation 97 89.84 High High
agonist 77 78.64 Quite High
Paracetamol 2 71.92 Quite High
Central nervous system 21 47.60 Quite Low
antagonist 14 38.68 Quite Low
tolerance 7 16.48 Low Low
addiction 5 11.04 Low Low
imagery 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis 6 99.74 Very High Very High Very High
Hepatitis Virus Infection 2 98.52 Very High Very High Very High
Overdose 1 97.48 Very High Very High Very High
Injury 34 93.64 High High
INFLAMMATION 119 89.84 High High
Hepatitis B Virus Infection 7 89.84 High High
Infection 79 89.44 High High
Cold Sores 367 84.32 Quite High
Viral Meningitis 4 81.28 Quite High
Meningitis 1 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are consistent with observations showing that TLR8 engagement is more effective than TLR7 activation in inducing proinflammatory cytokine production from human monocytes (37).
TLR8 Binding (engagement) of in monocytes associated with cytokine
1) Confidence 0.32 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.06 Pain Relevance 0.08
TLR3, TLR8 and TLR9 are recognized by virus-derived double stranded RNA (poly-I:C), virus-derived single stranded RNA (ssRNA) and unmethylated CpG motifs, respectively.
TLR8 Binding (recognized) of in poly
2) Confidence 0.16 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.67 Pain Relevance 0.10
Components of hepatitis viruses are ligands for TLR3, TLR7, TLR8 and TLR9, but not for TLR4.
TLR8 Neg (not) Binding (ligands) of associated with hepatitis
3) Confidence 0.10 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.84 Pain Relevance 0.52

General Comments

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