INT322086

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 8 Disease Relevance 2.68 Pain Relevance 1.12

signal transduction (OPN1SW) plasma membrane (OPN1SW) signal transducer activity (OPN1SW)

Anatomy Link Frequency urine 12 blood 4 OPN1SW (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 24 97.22 Pain 32 95.56 imagery 56 5.00 Central nervous system 8 5.00

Disease Link Frequency Relevance Heat Pain 32 95.56 Sprains And Strains 16 94.32 Fatigue 240 93.52 Chronic Fatigue Syndrome 88 54.92 Cognitive Disorder 72 50.00 Muscle Weakness 24 33.88 Muscle Disease 40 25.68 Neuropathy 16 24.48 Cramps 16 22.96 Disease 56 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Secondary objectives of the FACTS-2-FSHD trial are: - to evaluate the effects of AET and CBT on bodily functions and structures as defined by the International Classification of Functioning, Disability and Health (ICF): lower extremity muscle strength, pain, psychological well being, cardiovascular risk factors, aerobic exercise tolerance, sleeping pattern, as well as biomarkers in blood and urine and structural and metabolic muscle tissue characteristics. - to evaluate the effects of AET and CBT on the ICF level of activities: physical activity in daily life, self perceived functional status, and fall incidence. - to evaluate the effects of AET and CBT on the ICF level of participation: limitations in participation and autonomy and quality of life. - to evaluate the effects of AET and CBT on environmental and personal factors as defined by the ICF: coping style, illness cognitions, concentration problems, motivation, caregiver strain, experienced fatigue of the caregiver, social support and coping of the caregiver.

Regulation (effects) of Regulation (effects) of CBT in urine associated with pain, tolerance, fatigue and sprains and strains

1) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.40 Pain Relevance 0.14

Secondary objectives of the FACTS-2-FSHD trial are: - to evaluate the effects of AET and CBT on bodily functions and structures as defined by the International Classification of Functioning, Disability and Health (ICF): lower extremity muscle strength, pain, psychological well being, cardiovascular risk factors, aerobic exercise tolerance, sleeping pattern, as well as biomarkers in blood and urine and structural and metabolic muscle tissue characteristics. - to evaluate the effects of AET and CBT on the ICF level of activities: physical activity in daily life, self perceived functional status, and fall incidence. - to evaluate the effects of AET and CBT on the ICF level of participation: limitations in participation and autonomy and quality of life. - to evaluate the effects of AET and CBT on environmental and personal factors as defined by the ICF: coping style, illness cognitions, concentration problems, motivation, caregiver strain, experienced fatigue of the caregiver, social support and coping of the caregiver.

Regulation (effects) of Regulation (effects) of CBT in urine associated with pain, tolerance, fatigue and sprains and strains

2) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.33 Pain Relevance 0.14

Secondary objectives of the FACTS-2-FSHD trial are: - to evaluate the effects of AET and CBT on bodily functions and structures as defined by the International Classification of Functioning, Disability and Health (ICF): lower extremity muscle strength, pain, psychological well being, cardiovascular risk factors, aerobic exercise tolerance, sleeping pattern, as well as biomarkers in blood and urine and structural and metabolic muscle tissue characteristics. - to evaluate the effects of AET and CBT on the ICF level of activities: physical activity in daily life, self perceived functional status, and fall incidence. - to evaluate the effects of AET and CBT on the ICF level of participation: limitations in participation and autonomy and quality of life. - to evaluate the effects of AET and CBT on environmental and personal factors as defined by the ICF: coping style, illness cognitions, concentration problems, motivation, caregiver strain, experienced fatigue of the caregiver, social support and coping of the caregiver.

Regulation (participation) of Regulation (effects) of CBT in urine associated with pain, tolerance, fatigue and sprains and strains

3) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.33 Pain Relevance 0.14

Secondary objectives of the FACTS-2-FSHD trial are: - to evaluate the effects of AET and CBT on bodily functions and structures as defined by the International Classification of Functioning, Disability and Health (ICF): lower extremity muscle strength, pain, psychological well being, cardiovascular risk factors, aerobic exercise tolerance, sleeping pattern, as well as biomarkers in blood and urine and structural and metabolic muscle tissue characteristics. - to evaluate the effects of AET and CBT on the ICF level of activities: physical activity in daily life, self perceived functional status, and fall incidence. - to evaluate the effects of AET and CBT on the ICF level of participation: limitations in participation and autonomy and quality of life. - to evaluate the effects of AET and CBT on environmental and personal factors as defined by the ICF: coping style, illness cognitions, concentration problems, motivation, caregiver strain, experienced fatigue of the caregiver, social support and coping of the caregiver.

Regulation (participation) of Regulation (effects) of CBT in urine associated with pain, tolerance, fatigue and sprains and strains

4) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.28 Pain Relevance 0.14

Secondary objectives of the FACTS-2-FSHD trial are: - to evaluate the effects of AET and CBT on bodily functions and structures as defined by the International Classification of Functioning, Disability and Health (ICF): lower extremity muscle strength, pain, psychological well being, cardiovascular risk factors, aerobic exercise tolerance, sleeping pattern, as well as biomarkers in blood and urine and structural and metabolic muscle tissue characteristics. - to evaluate the effects of AET and CBT on the ICF level of activities: physical activity in daily life, self perceived functional status, and fall incidence. - to evaluate the effects of AET and CBT on the ICF level of participation: limitations in participation and autonomy and quality of life. - to evaluate the effects of AET and CBT on environmental and personal factors as defined by the ICF: coping style, illness cognitions, concentration problems, motivation, caregiver strain, experienced fatigue of the caregiver, social support and coping of the caregiver.

Regulation (effects) of in blood Regulation (effects) of CBT in urine associated with pain, tolerance, fatigue and sprains and strains

5) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.40 Pain Relevance 0.14

Secondary objectives of the FACTS-2-FSHD trial are: - to evaluate the effects of AET and CBT on bodily functions and structures as defined by the International Classification of Functioning, Disability and Health (ICF): lower extremity muscle strength, pain, psychological well being, cardiovascular risk factors, aerobic exercise tolerance, sleeping pattern, as well as biomarkers in blood and urine and structural and metabolic muscle tissue characteristics. - to evaluate the effects of AET and CBT on the ICF level of activities: physical activity in daily life, self perceived functional status, and fall incidence. - to evaluate the effects of AET and CBT on the ICF level of participation: limitations in participation and autonomy and quality of life. - to evaluate the effects of AET and CBT on environmental and personal factors as defined by the ICF: coping style, illness cognitions, concentration problems, motivation, caregiver strain, experienced fatigue of the caregiver, social support and coping of the caregiver.

Regulation (effects) of in blood Regulation (effects) of CBT in urine associated with pain, tolerance, fatigue and sprains and strains

6) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.33 Pain Relevance 0.14

Secondary objectives of the FACTS-2-FSHD trial are: - to evaluate the effects of AET and CBT on bodily functions and structures as defined by the International Classification of Functioning, Disability and Health (ICF): lower extremity muscle strength, pain, psychological well being, cardiovascular risk factors, aerobic exercise tolerance, sleeping pattern, as well as biomarkers in blood and urine and structural and metabolic muscle tissue characteristics. - to evaluate the effects of AET and CBT on the ICF level of activities: physical activity in daily life, self perceived functional status, and fall incidence. - to evaluate the effects of AET and CBT on the ICF level of participation: limitations in participation and autonomy and quality of life. - to evaluate the effects of AET and CBT on environmental and personal factors as defined by the ICF: coping style, illness cognitions, concentration problems, motivation, caregiver strain, experienced fatigue of the caregiver, social support and coping of the caregiver.

Regulation (participation) of in blood Regulation (effects) of CBT in urine associated with pain, tolerance, fatigue and sprains and strains

7) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.33 Pain Relevance 0.14

Secondary objectives of the FACTS-2-FSHD trial are: - to evaluate the effects of AET and CBT on bodily functions and structures as defined by the International Classification of Functioning, Disability and Health (ICF): lower extremity muscle strength, pain, psychological well being, cardiovascular risk factors, aerobic exercise tolerance, sleeping pattern, as well as biomarkers in blood and urine and structural and metabolic muscle tissue characteristics. - to evaluate the effects of AET and CBT on the ICF level of activities: physical activity in daily life, self perceived functional status, and fall incidence. - to evaluate the effects of AET and CBT on the ICF level of participation: limitations in participation and autonomy and quality of life. - to evaluate the effects of AET and CBT on environmental and personal factors as defined by the ICF: coping style, illness cognitions, concentration problems, motivation, caregiver strain, experienced fatigue of the caregiver, social support and coping of the caregiver.

Regulation (participation) of in blood Regulation (effects) of CBT in urine associated with pain, tolerance, fatigue and sprains and strains

8) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.28 Pain Relevance 0.14

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