INT322158

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Csk) plasma membrane (Csk) cytoplasm (Csk)
Anatomy Link Frequency
neuronal 1
Csk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 1 89.72 High High
nMDA receptor 1 86.72 High High
Pain 13 86.40 High High
chemokine 7 65.16 Quite High
Neuropathic pain 4 60.40 Quite High
Taxol 30 55.44 Quite High
vincristine 2 54.64 Quite High
Inflammation 10 42.00 Quite Low
dorsal root ganglion 16 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Status Epilepticus 106 95.20 Very High Very High Very High
Nociception 14 92.64 High High
Death 6 87.68 High High
Convulsion 10 87.00 High High
Pain 12 86.40 High High
Drug Induced Neurotoxicity 1 74.40 Quite High
Injury 3 68.48 Quite High
Cancer 4 64.16 Quite High
Neuropathic Pain 5 60.40 Quite High
Congenital Anomalies 1 45.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
increases N-methyl-D-aspartate (NMDA) receptor activity through IL-1RI-mediated activation of Src kinase family-mediated tyrosine phosphorylation of NR2A/B, which results in increased intracellular Ca2+ through an increase of its channel gating properties [74,79].
Phosphorylation (phosphorylation) of Src kinase
1) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.99 Pain Relevance 0.12
In accordance with that, Src tyrosine kinase phosphorylates membrane-associated tubulin of neuronal origin [92].
Phosphorylation (phosphorylates) of Src tyrosine kinase in neuronal
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.51 Pain Relevance 0.40

General Comments

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