INT322475

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.78
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (PGAP1) nuclease activity (PGAP1)
Anatomy Link Frequency
heart 2
PGAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 245 99.86 Very High Very High Very High
anesthesia 33 99.76 Very High Very High Very High
b2 receptor 9 99.58 Very High Very High Very High
isoflurane 18 99.50 Very High Very High Very High
Analgesic 30 99.16 Very High Very High Very High
Inflammation 29 98.56 Very High Very High Very High
adenocard 186 98.34 Very High Very High Very High
Perioperative pain 30 97.16 Very High Very High Very High
bradykinin 123 92.92 High High
Preemptive analgesia 20 91.80 High High
Disease Link Frequency Relevance Heat
Pharyngitis 170 100.00 Very High Very High Very High
Nociception 20 99.84 Very High Very High Very High
INFLAMMATION 31 98.56 Very High Very High Very High
Post Operative Pain 30 97.16 Very High Very High Very High
Disease 23 91.24 High High
Hypothermia 6 89.36 High High
Pain 37 83.36 Quite High
Injury 28 83.16 Quite High
Hoarseness 15 82.20 Quite High
Cough 15 81.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it would be useful if the intravenous ketamine as an analgesic adjunct to general anesthesia could also reduce POST.
Negative_regulation (reduce) of POST associated with pharyngitis, anesthesia, ketamine and analgesic
1) Confidence 0.36 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908222 Disease Relevance 0.98 Pain Relevance 1.19
We expected that the preemptive effect of ketamine could also reduce POST.
Negative_regulation (reduce) of POST associated with pharyngitis and ketamine
2) Confidence 0.36 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908222 Disease Relevance 0.60 Pain Relevance 1.19
Intravenous injection of low dose ketamine was not effective for reducing POST.



Negative_regulation (reducing) of POST associated with pharyngitis and ketamine
3) Confidence 0.26 Published 2010 Journal Korean Journal of Anesthesiology Section Abstract Doc Link PMC2908222 Disease Relevance 0.45 Pain Relevance 0.28
We infused low dose ketamine intravenously throughout the period of endotracheal intubation under the hypothesis that preemptive ketamine would reduce POST.
Negative_regulation (reduce) of POST associated with pharyngitis and ketamine
4) Confidence 0.26 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908222 Disease Relevance 0.73 Pain Relevance 0.69
The sample size was estimated from the assumption that a 50% reduction in the incidence of POST would be clinically relevant.
Negative_regulation (reduction) of POST associated with pharyngitis
5) Confidence 0.26 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908222 Disease Relevance 1.24 Pain Relevance 0.22
There was a statistically significant reduction in post-treatment IL-1?
Negative_regulation (reduction) of post-treatment
6) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 0.20 Pain Relevance 0.07
At present, only two studies have shown, in mouse and rat heart, that isoflurane and sevoflurane-induced PostC was abolished by treatment with ROS scavengers [3,8].
Negative_regulation (abolished) of PostC in heart associated with isoflurane
7) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.08 Pain Relevance 0.49
Furthermore, although our experimental groups showed comparable demographic data (table 1), age has been shown to impair ischemic PostC in senescent mouse hearts [39-41], and should also be considered in patients.
Negative_regulation (impair) of PostC in hearts
8) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.49 Pain Relevance 0.17
Pre-treatment with adenosine receptors inhibitor (SPT) and specific B2 bradykinin receptor' inhibitor (HOE140) abolished desflurane-induced PostC.
Negative_regulation (abolished) of PostC associated with adenocard and b2 receptor
9) Confidence 0.01 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0 Pain Relevance 0.40

General Comments

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