INT322509

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.26 Pain Relevance 0

peptidase activity (Ctsb) mitochondrion (Ctsb) extracellular space (Ctsb) extracellular region (Ctsb) lysosome (Ctsb) cytoplasm (Ctsb)

Ctsb (Mus musculus)

Pain Link Frequency Relevance Heat cINOD 2 5.00

Disease Link Frequency Relevance Heat Glioma 52 99.84 Cancer 70 96.64 Adhesions 4 83.52 Metastasis 4 82.56 Hyperplasia 4 25.76 Apoptosis 18 5.00 Colon Cancer 4 5.00 Retinoblastoma 2 5.00 Lung Cancer 2 5.00 Skin Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cathepsin B and urokinase-type plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas and, as such, are attractive targets for gene therapy.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Cathepsin B associated with glioma

1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.85 Pain Relevance 0

Cathepsin B and urokinase plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Cathepsin B associated with glioma

2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.41 Pain Relevance 0

General Comments

This test has worked.