INT322996

Context Info Confidence 0.56 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 8 Disease Relevance 4.04 Pain Relevance 2.79

SSD (Homo sapiens)

Pain Link Frequency Relevance Heat cannabis 1470 99.90 Cannabinoid receptor 12 90.00 opiate 6 88.64 alcohol 102 85.92 drug abuse 42 75.24 Catecholamine 6 66.88 Dopamine 18 65.04 noradrenaline 6 64.24 Cannabinoid 66 60.52 Nicotine 42 21.76

Disease Link Frequency Relevance Heat Cancer 82 100.00 Apoptosis 54 100.00 Schizophrenia 186 97.08 Psychosis 366 93.16 Disease 24 88.28 Death 50 88.00 Cervical Cancer 10 82.80 Ovarian Cancer 6 80.00 Lung Cancer 8 76.96 Drug Dependence 42 75.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Many recent advances have been made on the third hypothesis, where it is assumed that a third factor increases the risk for SSD in some cannabis users.

Positive_regulation (increases) of SSD associated with cannabis

1) Confidence 0.56 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.30 Pain Relevance 0.34

They are as follows: a) cannabis use causes SSD (causal model); b) patients with SSD are attracted to cannabis use; c) cannabis use induces SSD in a minority with background vulnerability [9,10].

Positive_regulation (induces) of SSD associated with cannabis

2) Confidence 0.56 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.33 Pain Relevance 0.55

Male gender and younger age were associated with an increased risk for SSD[6].

Positive_regulation (increased) of SSD

3) Confidence 0.56 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.66 Pain Relevance 0.38

They are as follows: a) cannabis use causes SSD (causal model); b) patients with SSD are attracted to cannabis use; c) cannabis use induces SSD in a minority with background vulnerability [9,10].

Positive_regulation (causes) of SSD associated with cannabis

4) Confidence 0.56 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.40 Pain Relevance 0.58

Cannabis use causes SSD (causal model)

Positive_regulation (causes) of SSD associated with cannabis

5) Confidence 0.37 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.08 Pain Relevance 0.62

While assuredly other gender related and social factors may play a role in this, there was nonetheless a statistically significant increase in the prevalence of SSD among men (see above) in our sample.

Positive_regulation (increase) of SSD

6) Confidence 0.37 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.06 Pain Relevance 0.31

Similar effect of SSd was detected in Hela cells, albeit SSd by itself is slightly more toxic than SSa (Figure 1C and 1D).

Positive_regulation (effect) of SSd

7) Confidence 0.29 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 1.22 Pain Relevance 0

In this study we demonstrated that both SSa and SSd potently sensitize a number of human cancer cells to cisplatin-induced apoptosis through ROS accumulation.

Positive_regulation (accumulation) of SSd associated with cancer and apoptosis

8) Confidence 0.27 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.99 Pain Relevance 0

General Comments

This test has worked.