INT322999

Context Info Confidence 0.39 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 3.86 Pain Relevance 4.28

Anatomy Link Frequency blood 1 SSD (Homo sapiens)

Pain Link Frequency Relevance Heat cannabis 2205 100.00 opiate 9 94.84 Cannabinoid 99 92.76 alcohol 153 92.12 Cannabinoid receptor 18 89.12 Neurotransmitter 36 85.96 drug abuse 63 83.04 Nicotine 63 56.72 Catecholamine 9 48.88 Dopamine 27 47.04

Disease Link Frequency Relevance Heat Psychosis 549 100.00 Neutropenia 1 98.68 Leukopenia 5 98.44 Schizophrenia 279 96.52 Hypersensitivity 13 94.92 Stress 12 94.20 Burns 13 93.92 Amnesia 9 93.64 Mental Disorders 81 89.28 Drug Dependence 63 83.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, there is strong epidemiological evidence including that of this study, for an association between cannabis use and SSD.

SSD Binding (association) of associated with cannabis

1) Confidence 0.39 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.36 Pain Relevance 0.60

One is regarding the actual mechanism of the association between cannabis and SSD.

SSD Binding (association) of associated with cannabis

2) Confidence 0.39 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.49 Pain Relevance 0.53

e) To summarize the findings to identify an association between cannabis use and subsequent development of SSD

SSD Binding (association) of associated with cannabis

3) Confidence 0.30 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.31 Pain Relevance 0.56

The question here is, since those at risk of getting CIP or SSD with cannabis are few, is it justified to incarcerate the vast majority of people who may use cannabis without any harm?.

SSD Binding (getting) of associated with cannabis and psychosis

4) Confidence 0.30 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.26 Pain Relevance 0.34

The role of environmental factors in constituting a vulnerability to SSD with cannabis use is less explored (see introduction).

SSD Binding (vulnerability) of associated with cannabis

5) Confidence 0.30 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.35 Pain Relevance 0.38

Three different hypotheses were mentioned earlier regarding the association between cannabis use and SSD[10].

SSD Binding (association) of associated with cannabis

6) Confidence 0.29 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.08 Pain Relevance 0.62

As mentioned previously, many studies published since 1987 have shown an association between cannabis use and SSD[3].

SSD Binding (association) of associated with cannabis

7) Confidence 0.29 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.24 Pain Relevance 0.51

Association between cannabis and SSD

SSD Binding (Association) of associated with cannabis

8) Confidence 0.29 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.07 Pain Relevance 0.55

Aims To assess the characteristics of cannabis use and its association with SSD in a cohort of psychiatrically ill patients and discuss the implications for policy development Methods

SSD Binding (association) of associated with cannabis

9) Confidence 0.29 Published 2010 Journal Subst Abuse Treat Prev Policy Section Abstract Doc Link PMC2910013 Disease Relevance 0.31 Pain Relevance 0.19

Leukopenia/neutropenia was reported in nine patients with a mean WBC of 2,680/mm3 where SSD was associated with immature band forms in peripheral blood, but WBC normalised within 2-3 days [124].

SSD Binding (associated) of in blood associated with neutropenia and leukopenia

10) Confidence 0.16 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC3003978 Disease Relevance 1.40 Pain Relevance 0

General Comments

This test has worked.