INT323229

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.63
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Tgs1) nucleus (Tgs1) cytoplasm (Tgs1)
Anatomy Link Frequency
fat 1
heart 1
Tgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 6 88.52 High High
Potency 9 76.20 Quite High
alcohol 6 5.00 Very Low Very Low Very Low
Restless leg syndrome 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 128 99.80 Very High Very High Very High
Obesity 7 98.94 Very High Very High Very High
Congenital Anomalies 62 97.32 Very High Very High Very High
Diabetes Mellitus 108 96.74 Very High Very High Very High
Coronary Artery Disease 57 95.98 Very High Very High Very High
Overweight 6 93.44 High High
Hypertriglyceridemia 63 66.56 Quite High
Cardiovascular Disease 44 57.76 Quite High
Metabolic Syndrome 36 57.68 Quite High
Insulin Resistance 15 52.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No lipid abnormalities were found in 21.1% of statin-treated patients, isolated LDL-C not at goal was found in 25.0% of patients, LDL-C not at goal + low HDL-C and/or elevated TGs in 33.6% of patients, LDL-C at goal + low HDL-C and/or elevated TGs were found in 20.3% of patients.
Positive_regulation (elevated) of TGs associated with congenital anomalies and disorder of lipid metabolism
1) Confidence 0.17 Published 2010 Journal Clin Res Cardiol Section Body Doc Link PMC2959161 Disease Relevance 1.30 Pain Relevance 0.08
No lipid abnormalities were found in 21.1% of statin-treated patients, isolated LDL-C not at goal was found in 25.0% of patients, LDL-C not at goal + low HDL-C and/or elevated TGs in 33.6% of patients, LDL-C at goal + low HDL-C and/or elevated TGs were found in 20.3% of patients.
Positive_regulation (elevated) of TGs associated with congenital anomalies and disorder of lipid metabolism
2) Confidence 0.17 Published 2010 Journal Clin Res Cardiol Section Body Doc Link PMC2959161 Disease Relevance 1.38 Pain Relevance 0.08
Corresponding numbers in patients with diabetes mellitus and in patients with coronary heart disease without concomitant diabetes mellitus were: no lipid abnormalities in 19.8/28.2% of patients, isolated LDL-C not at goal was found in 17.2/27.8% of patients, LDL-C not at goal and/or low HDL-C and/or elevated TGs in 36.2/26.9% of patients, LDL-C at goal and/or low HDL-C and/or elevated TGs were found in 26.9/17.0% of patients (Fig. 2a, b).Fig. 2a Lipid profile in all patients. b Lipid profile in diabetic patients and patients with coronary heart disease but no concomitant diabetes mellitus
Positive_regulation (elevated) of TGs in heart associated with coronary artery disease, congenital anomalies, diabetes mellitus and disorder of lipid metabolism
3) Confidence 0.17 Published 2010 Journal Clin Res Cardiol Section Body Doc Link PMC2959161 Disease Relevance 1.55 Pain Relevance 0.07
Most studies comparing F and S have shown that both sugars behave in essentially similar manners, pointing to the fact that F is actually the culprit.94–97 No differences in energy balance were found between HFCS, S and milk.98 When compared to G, HFCS and S always lead to higher TG or glucose/insulin responses over a 24-h period.99 In a study investigating the effects of 34% F in 3 different diets (F, F+G and S), a reduction in insulin sensitivity in rats was observed in every regimen.97 Several studies have compared F and G, and in a one-week study, F increased VLDL more than G, but intramuscular lipids were higher with G.100 Essentially the same qualitative difference was found in another study that extended the comparison to one month.96 Giving sweetened beverages to overweight or obese subjects for up to 10 weeks showed that F but not G increased lipid synthesis and visceral adiposity and reduced insulin sensitivity; G administration led to increased subcutaneous fat, which is relatively harmless.101 When F or G was administered with meals, obese patients showed lower insulin and leptin levels but increased postprandial TGs; HTG lasted for over 24 hours in the insulin-resistant subgroup.12
Positive_regulation (increased) of TGs in fat associated with obesity and overweight
4) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 0.39 Pain Relevance 0

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