INT323368

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 6.03
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Dtnbp1) endoplasmic reticulum (Dtnbp1) plasma membrane (Dtnbp1)
nucleus (Dtnbp1) cytoplasm (Dtnbp1)
Anatomy Link Frequency
muscle 1
brain 1
Dtnbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 7 96.00 Very High Very High Very High
Dopamine 56 69.52 Quite High
cerebral cortex 7 65.12 Quite High
Glutamate 21 59.92 Quite High
agonist 7 57.00 Quite High
Glutamate receptor 7 56.68 Quite High
Nicotine 91 52.96 Quite High
opiate 112 51.92 Quite High
addiction 210 51.36 Quite High
alcohol 105 49.84 Quite Low
Disease Link Frequency Relevance Heat
Psychosis 49 100.00 Very High Very High Very High
Schizophrenia 273 99.92 Very High Very High Very High
Manic Depressive Disorder 21 99.36 Very High Very High Very High
Cognitive Disorder 7 98.88 Very High Very High Very High
Anxiety Disorder 63 67.36 Quite High
Traumatic Stress Disorders 14 56.48 Quite High
Post-traumatic Stress Disorder 126 54.32 Quite High
Opiate Addiction 91 51.92 Quite High
Alcohol Addiction 63 49.84 Quite Low
Attention Deficit Hyperactivity Disorder 7 38.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DTNBP1 is associated with other psychotic conditions.
DTNBP1 Binding (associated) of associated with psychosis
1) Confidence 0.48 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 1.20 Pain Relevance 0.19
Association with DTNBP1 was found with bipolar disorder but only in a small subgroup characterised by the complication of psychotic features during episodes of mood disturbance [15].
DTNBP1 Binding (Association) of associated with manic depressive disorder and psychosis
2) Confidence 0.48 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 1.26 Pain Relevance 0.16
Dystrobrevin binding protein 1 (DTNBP1) is a neuronal protein that binds to alpha- and beta-dystrobrevin in muscle and brain [1].
DTNBP1 Binding (binds) of in brain
3) Confidence 0.36 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 0.32 Pain Relevance 0.08
Methamphetamine psychosis is clinically similar to schizophrenia [16,17] and a recent study hypothesised that DTNBP1 may also be associated with substance-induced psychoses [18].
DTNBP1 Binding (associated) of associated with psychosis and schizophrenia
4) Confidence 0.36 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 1.15 Pain Relevance 0.10
A number of studies have found associations between dysbindin (DTNBP1) polymorphisms and schizophrenia.
DTNBP1 Binding (associations) of associated with schizophrenia
5) Confidence 0.36 Published 2010 Journal Behav Brain Funct Section Abstract Doc Link PMC2911395 Disease Relevance 0.61 Pain Relevance 0.10
Significant associations with methamphetamine psychosis and DTNBP1 variation was identified in a case-control study [18].
DTNBP1 Binding (associations) of associated with psychosis
6) Confidence 0.31 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 1.18 Pain Relevance 0.07
Dystrobrevin binding protein 1 (DTNBP1) is a neuronal protein that binds to alpha- and beta-dystrobrevin in muscle and brain [1].
DTNBP1 Binding (binds) of in muscle
7) Confidence 0.12 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 0.32 Pain Relevance 0.08

General Comments

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