INT32354

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Context Info
Confidence 0.33
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.13
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
hypothalamus 4
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 10 100.00 Very High Very High Very High
agonist 2 95.32 Very High Very High Very High
antagonist 2 88.32 High High
Dopamine 2 87.88 High High
Neurotransmitter 4 76.76 Quite High
tolerance 22 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 28 79.84 Quite High
Weight Loss 3 36.32 Quite Low
Body Weight 3 34.32 Quite Low
Stress 14 21.52 Low Low
Obesity 6 12.32 Low Low
Impaired Glucose Tolerance 22 5.00 Very Low Very Low Very Low
Insulin Resistance 11 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Parkinson's Disease 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EB attenuated the effect of CLON on IR-BE levels in the AP and hypothalamus.
Negative_regulation (attenuated) of Regulation (effect) of IR-BE in hypothalamus associated with clonidine
1) Confidence 0.33 Published 1986 Journal Peptides Section Abstract Doc Link 2948165 Disease Relevance 0 Pain Relevance 0.65
The effect of EB on IR-BE levels in the AP and NIL was reversed by administration of HALO, while EB and HALO appeared to act independently on the hypothalamus.
Negative_regulation (reversed) of Regulation (effect) of IR-BE in hypothalamus
2) Confidence 0.33 Published 1986 Journal Peptides Section Abstract Doc Link 2948165 Disease Relevance 0 Pain Relevance 0.44
We found a decrease of the 2-h glucose and HbA1c concentrations in the IGTslow and IGTfast groups and a decrease of the fasting glucose and HOMA-IR values in the IGTfast group [24].
Negative_regulation (decrease) of Regulation (values) of HOMA-IR
3) Confidence 0.01 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.13 Pain Relevance 0

General Comments

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