INT323860

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.03 Pain Relevance 0.15

transport (HBM)

Anatomy Link Frequency blood 2 HBM (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 12 97.44 Arthritis 12 66.20 Osteoarthritis 56 50.00 Inflammatory response 3 46.32 Inflammatory mediators 2 36.64 fibrosis 3 15.84 Inflammation 23 5.00 metalloproteinase 13 5.00 Pain 7 5.00 corticosteroid 2 5.00

Disease Link Frequency Relevance Heat Hemarthrosis 4 97.84 Hypertrophy 1 94.96 Siderosis 1 93.68 Synovitis 1 87.20 Apoptosis 17 80.16 Hemorrhage 8 68.48 Arthritis 16 66.20 Injury 58 54.64 Frailty 58 50.00 Rupture 3 49.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hemoglobin degradation products such as deoxyhemoglobin, methemoglobin, and hemosiderin appear to mediate the blood-induced damage.

Positive_regulation (mediate) of Protein_catabolism (degradation) of Hemoglobin in blood

1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 1.03 Pain Relevance 0.15

General Comments

This test has worked.