INT323883

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.39
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) nucleolus (BMI1)
nucleus (BMI1) lipid metabolic process (LEP) cytoplasm (BMI1)
Anatomy Link Frequency
chondrocytes 1
BMI1 (Homo sapiens)
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 108 98.88 Very High Very High Very High
Inflammatory mediators 4 72.64 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 208 100.00 Very High Very High Very High
Osteoarthritis 108 98.88 Very High Very High Very High
Overweight 26 94.32 High High
INFLAMMATION 14 72.24 Quite High
Body Weight 4 50.80 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Weight Loss 2 5.00 Very Low Very Low Very Low
Starvation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the BMI changed the leptin dose-response of chondrocytes.
BMI Regulation (changed) of leptin in chondrocytes associated with obesity
1) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.26 Pain Relevance 0.12
The activation of STAT has been investigated to determine whether BMI may affect the leptin signalling pathway.
BMI Spec (may) Regulation (affect) of leptin associated with obesity
2) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.13 Pain Relevance 0.10

General Comments

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