INT324117

Context Info Confidence 0.21 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.36

signal transduction (NTF3) extracellular region (NTF3) cytoplasmic membrane-bounded vesicle (NTF3) plasma membrane (NTF3) cell-cell signaling (NTF3)

Anatomy Link Frequency ciliary 2 NTF3 (Homo sapiens)

Pain Link Frequency Relevance Heat Nerve growth factor 22 95.44 Neuropeptide 2 91.96 Glutamate receptor 4 29.84 Glutamate 14 26.12 Action potential 2 13.80 Spinal cord 78 5.00 Inflammation 8 5.00 Central nervous system 6 5.00 ketamine 2 5.00 Buprenorphine 2 5.00

Disease Link Frequency Relevance Heat Death 8 34.64 Spinal Cord Injury 106 5.00 Injury 66 5.00 Contusions 8 5.00 INFLAMMATION 8 5.00 Apoptosis 8 5.00 Rheumatoid Arthritis 4 5.00 Lifespan 4 5.00 Demyelinating Disease 2 5.00 Toxicity 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further analysis using real-time PCR revealed a 10-fold increase in NT-3, a 23-fold increase in NT-4, an 18-fold increase in VEGF, a 3.5-fold increase in CNTF (ciliary neurotrophic factor), a 6-fold increase in IL10, a 121-fold increase in NRG4 (neuregulin 4), and a 275-fold increase in NPY (neuropeptide Y) when compared to hFib controls.

Positive_regulation (increase) of NT-3 in ciliary associated with neuropeptide

1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.18

Further analysis using real-time PCR revealed a 10-fold increase in NT-3, a 23-fold increase in NT-4, an 18-fold increase in VEGF, a 3.5-fold increase in CNTF (ciliary neurotrophic factor), a 6-fold increase in IL10, a 121-fold increase in NRG4 (neuregulin 4), and a 275-fold increase in NPY (neuropeptide Y) when compared to hFib controls.

Positive_regulation (increase) of NT-3 in ciliary associated with neuropeptide

2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.18

General Comments

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