INT32412

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Context Info
Confidence 0.21
First Reported 1987
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.36
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Pomc) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc)
extracellular space (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
3rd ventricle 2
Penk (Rattus norvegicus)
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 22 100.00 Very High Very High Very High
narcan 3 99.74 Very High Very High Very High
Opioid 5 75.00 Quite High
antagonist 1 33.64 Quite Low
opiate 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Lordosis 10 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential effects of beta-endorphin and Met- and Leu-enkephalin on steroid hormone-induced lordosis in ovariectomized female rats.
Leu-enkephalin Regulation (effects) of beta-endorphin associated with narcan, enkephalin and lordosis
1) Confidence 0.21 Published 1997 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 9408184 Disease Relevance 0.36 Pain Relevance 0.72
The effect of beta-endorphin, met-enkephalin and leu-enkephalin on cold-stimulated TSH and prolactin secretion after infusion of the drugs into the 3rd ventricle or into the posterior hypothalamus (PH) was investigated in male rats. beta-endorphin (0.25 microgram/rat, but not 0.05, 0.5 and 1 microgram/rat) increased and met-enkephalin (20 and 100 micrograms/rat) decreased TSH secretion when infused into the 3rd ventricle.
leu-enkephalin Regulation (effect) of beta-endorphin in 3rd ventricle associated with enkephalin
2) Confidence 0.04 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2951956 Disease Relevance 0 Pain Relevance 0.48
The effect of beta-endorphin, met-enkephalin and leu-enkephalin on cold-stimulated TSH and prolactin secretion after infusion of the drugs into the 3rd ventricle or into the posterior hypothalamus (PH) was investigated in male rats. beta-endorphin (0.25 microgram/rat, but not 0.05, 0.5 and 1 microgram/rat) increased and met-enkephalin (20 and 100 micrograms/rat) decreased TSH secretion when infused into the 3rd ventricle.
met-enkephalin Regulation (effect) of beta-endorphin in 3rd ventricle associated with enkephalin
3) Confidence 0.04 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2951956 Disease Relevance 0 Pain Relevance 0.42

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