INT324859

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Hmgb1 (Mus musculus)
ecs (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 57.12 Quite High
ischemia 4 49.28 Quite Low
cytokine 1 42.16 Quite Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhagic Shock 32 99.96 Very High Very High Very High
American Trypanosomiasis 1 85.36 High High
Bacterial Respiratory Disease 1 76.88 Quite High
Pneumonia 5 57.52 Quite High
Hepatitis 1 51.28 Quite High
Injury 18 49.96 Quite Low
Cv Unclassified Under Development 4 49.28 Quite Low
INFLAMMATION 15 48.44 Quite Low
Adult Respiratory Distress Syndrome 27 14.64 Low Low
Shock 7 14.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have reported that in HS, HMGB1 through TLR4 signaling upregulates TLR2 in ECs, and this upregulation associates with an amplified EC function including augmented activation of NADPH oxidase and expression of ICAM-1 in response to TLR2 activation by HMGB1 [48].
HMGB1 Positive_regulation (upregulates) of ECs associated with hemorrhagic shock
1) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.74 Pain Relevance 0.03

General Comments

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