INT324927

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 4.29 Pain Relevance 2.96

plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)

Syt17 (Rattus norvegicus) Bdkrb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat B1 receptor 194 100.00 bradykinin 52 100.00 agonist 22 98.68 Inflammation 18 90.64 cytokine 18 89.60 Neuropathic pain 12 86.76 Eae 6 78.56 Spinal sensitization 2 76.40 Hyperalgesia 20 73.68 Pain 24 69.28

Disease Link Frequency Relevance Heat INFLAMMATION 26 90.64 Hyperglycemia 16 86.96 Neuropathic Pain 128 86.76 Diabetes Mellitus 130 85.76 Nociception 16 85.24 Stress 6 84.40 Targeted Disruption 2 81.76 Inflammatory Pain 2 78.56 Hyperalgesia 42 73.68 Pain 24 69.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The B1R is activated by the active metabolites des-Arg9-BK and Lys-des-Arg9-BK and has a low level of expression in healthy tissues [10].

des-Arg9-BK Positive_regulation (activated) of B1R associated with b1 receptor and bradykinin

1) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 2.13 Pain Relevance 1.48

The B1R is activated by the active metabolites des-Arg9-BK and Lys-des-Arg9-BK and has a low level of expression in healthy tissues [10].

Lys-des-Arg9-BK Positive_regulation (activated) of B1R associated with b1 receptor and bradykinin

2) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 2.15 Pain Relevance 1.49

General Comments

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