INT325154

Context Info Confidence 0.07 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.10 Pain Relevance 0

nucleoplasm (CDKN1B, CCNE2) cytosol (CDKN1B, CCNE2) nucleus (CDKN1B, CCNE2) endosome (CDKN1B) cytoplasm (CDKN1B) cell cycle (CDKN1B)

CDKN1B (Homo sapiens) CCNE2 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 2 5.00 Inflammation 2 5.00 aspirin 1 5.00 tolerance 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 22 53.36 Cancer 26 51.12 Colon Cancer 25 50.00 Death 5 33.68 Malaria 3 5.00 Toxicity 2 5.00 Hepatitis 2 5.00 Systemic Lupus Erythematosus 2 5.00 INFLAMMATION 2 5.00 Rheumatoid Arthritis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, we speculated that the resulting increased p21Cip1 and p27Kip1, by binding to and consequently inhibiting the cyclin E/CDK2 complex activity, potentiated the cell cycle arrest in G0/G1 phase, as also reported by others [28].

p27Kip1 Negative_regulation (inhibiting) of cyclin E

1) Confidence 0.07 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.10 Pain Relevance 0

General Comments

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