INT325348

Context Info Confidence 0.61 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.12 Pain Relevance 0.07

cell proliferation (THPO) extracellular space (THPO) extracellular region (THPO)

THPO (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 2 87.76 Bioavailability 2 61.28 agonist 2 23.80 fibrosis 10 5.00 corticosteroid 4 5.00 headache 4 5.00 palliative 2 5.00 tolerance 2 5.00 cva 2 5.00

Disease Link Frequency Relevance Heat Thrombocytopenia 94 60.32 Purpura 2 50.00 Heparin-induced Thrombocytopenia 4 34.08 Myelodysplastic Syndromes 10 32.00 Hepatitis 4 29.20 Infection 8 28.24 Hemorrhage 24 22.32 Cancer 2 7.08 Fibrosis 10 5.00 Malignant Neoplastic Disease 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Physiologic control of TPO production

Regulation (control) of Gene_expression (production) of TPO

1) Confidence 0.61 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.06 Pain Relevance 0

These activities of eltrombopag have been shown to be dependent on the expression of TPO receptor.

Regulation (dependent) of Gene_expression (expression) of TPO receptor

2) Confidence 0.61 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

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