INT325933

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.75
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ezr) cytosol (Ezr) nucleolus (Ezr)
plasma membrane (Ezr) cytoskeleton (Ezr) intracellular (Ezr)
Anatomy Link Frequency
lymph node 2
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 22 48.56 Quite Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 82 97.98 Very High Very High Very High
Pancreatic Cancer 44 96.98 Very High Very High Very High
Adenocarcinoma 54 71.60 Quite High
Pancreatitis 22 48.56 Quite Low
Cancer 54 18.96 Low Low
Glioma 2 8.64 Low Low
Malignant Neoplastic Disease 10 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Pancreatic Ductal Carcinoma 6 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although a recent study has shown that overexpression of pEzrin(Tyr353) in pancreatic cancers is associated with positive lymph node metastasis, less differentiation, pAkt overexpression, and shorter survival times [27], we did not observe any change of ezrin phosphorylation in either the ezrin overexpressing or the ezrin silencing MiaPaCa-2 cells.
Regulation (change) of Phosphorylation (phosphorylation) of ezrin in lymph node associated with pancreatic cancer and metastasis
1) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.38 Pain Relevance 0
Therefore, phosphorylation of ezrin may not affect the motility and invasion ability of MiaPaCa-2 cells in vitro.
Neg (not) Spec (may) Regulation (affect) of Phosphorylation (phosphorylation) of ezrin
2) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.38 Pain Relevance 0

General Comments

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