INT325937

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.17
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ezr) cytosol (Ezr) nucleolus (Ezr)
plasma membrane (Ezr) cytoskeleton (Ezr) intracellular (Ezr)
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 66.96 Quite High
Chronic pancreatitis 44 32.48 Quite Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 108 98.12 Very High Very High Very High
Anaplastic Astrocytoma 4 97.96 Very High Very High Very High
Melanoma 8 96.20 Very High Very High Very High
Malignant Neoplastic Disease 20 95.68 Very High Very High Very High
Glioma 4 95.16 Very High Very High Very High
Rhabdomyosarcoma 8 87.92 High High
Stress 4 87.28 High High
Metastasis 164 82.80 Quite High
Pancreatic Cancer 88 82.60 Quite High
Adhesions 12 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, immunohistochemical analysis has demonstrated a significant correlation between increased ezrin immunoreactivity and a high histological grade in astrocytoma [16].
Positive_regulation (increased) of ezrin associated with anaplastic astrocytoma
1) Confidence 0.50 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.85 Pain Relevance 0
Ezrin overexpression inducing Erk1/2 activation
Positive_regulation (activation) of Ezrin
2) Confidence 0.50 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.28 Pain Relevance 0
Our results showed that increased level of the ezrin protein was correlated with an increase in anchorage-independent growth of tumor cells, consistent with the previous finding in glioma cells [13].
Positive_regulation (increased) of ezrin protein associated with cancer and glioma
3) Confidence 0.46 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.74 Pain Relevance 0.03
To study the function of the Vil2 gene in MiaPaCa-2 cells, the pcb6-ezrin-VSV-G vector was adopted to stably overexpress the ezrin protein, and the pcb6 vector was used as a control.
Positive_regulation (overexpress) of ezrin protein
4) Confidence 0.46 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.30 Pain Relevance 0

General Comments

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