INT326

Context Info Confidence 0.76 First Reported 1976 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 105 Total Number 105 Disease Relevance 35.87 Pain Relevance 34.93

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)

Anatomy Link Frequency plasma 19 uterus 6 blood 5 thyroid 5 pituitary 4 Gnrhr (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 83 100.00 Pain 77 100.00 agonist 30 100.00 Cholecystokinin 5 100.00 Morphine 88 99.92 Opioid 22 99.78 methadone 21 99.78 Dopamine 9 99.68 cryotherapy 5 99.68 narcan 63 99.64

Disease Link Frequency Relevance Heat Pain 80 100.00 Growth Hormone Deficiency 24 100.00 Hypothermia 9 100.00 Increased Venous Pressure Under Development 7 100.00 Eating Disorder 7 99.96 Congenital Anomalies 48 99.92 Myalgia 4 99.90 Cushing's Syndrome / Hypercortisolism 8 99.84 Galactorrhea 2 99.84 Hypotension 6 99.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The concomitant administration of morphine and naloxone completely prevented the effect of morphine on GnRH gene expression indicating the inhibitory influence of morphine is likely to be mediated by opioid receptors.

Gene_expression (expression) of GnRH gene associated with narcan, opioid receptor and morphine

1) Confidence 0.76 Published 1993 Journal Neuroreport Section Abstract Doc Link 8477057 Disease Relevance 0 Pain Relevance 1.21

Opioid regulation of gonadotropin-releasing hormone gene expression in the male rat brain as studied by in situ hybridization.

Gene_expression (expression) of gonadotropin-releasing hormone in brain associated with opioid

2) Confidence 0.76 Published 1993 Journal Neuroreport Section Title Doc Link 8477057 Disease Relevance 0 Pain Relevance 1.16

In order to investigate the role of opiates in the regulation of GnRH gene expression in the rat brain, we studied the effects of chronic administration of the opioid drug morphine and an opiate receptor antagonist naloxone on GnRH mRNA levels as measured by in situ hybridization.

Gene_expression (expression) of GnRH gene in brain associated with antagonist, narcan, opiate, opioid and morphine

3) Confidence 0.76 Published 1993 Journal Neuroreport Section Abstract Doc Link 8477057 Disease Relevance 0 Pain Relevance 0.98

There is only one rheumatic disorder, namely acromegaly, in which abnormalities of growth hormone production play a major etiologic role.

Gene_expression (production) of growth hormone associated with acromegaly and congenital anomalies

4) Confidence 0.75 Published 2005 Journal Curr Pain Headache Rep Section Abstract Doc Link 16157062 Disease Relevance 0.61 Pain Relevance 0.20

There is only one rheumatic disorder, namely acromegaly, in which abnormalities of growth hormone production play a major etiologic role.

Gene_expression (production) of growth hormone associated with acromegaly and congenital anomalies

5) Confidence 0.75 Published 2004 Journal Curr Rheumatol Rep Section Abstract Doc Link 15251074 Disease Relevance 0.61 Pain Relevance 0.20

In comparison with model group, hypothalamic GnRH mRNA, ovary GnRH mRNA, pituitary GnRH-R mRNA and uterus ER mRNA expressions in acupuncture and ELI groups were suppressed significantly (P<0.05), while uterus PR mRNA expressions in the later two groups were up-regulated obviously (P<0.05).

Gene_expression (expressions) of GnRH-R in uterus

6) Confidence 0.71 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0 Pain Relevance 0

In comparison with model group, hypothalamic GnRH mRNA, ovary GnRH mRNA, pituitary GnRH-R mRNA and uterus ER mRNA expressions in acupuncture and ELI groups were suppressed significantly (P<0.05), while uterus PR mRNA expressions in the later two groups were up-regulated obviously (P<0.05).

Gene_expression (expressions) of GnRH mRNA in uterus

7) Confidence 0.71 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0 Pain Relevance 0

Apomorphine did not produce a statistically significant increase in plasma growth hormone concentration when administered directly into the the third ventricle, and pimozide failed to abolish the increase in plasma growth hormone produced by L-dopa.

Gene_expression (produced) of plasma growth hormone in plasma

8) Confidence 0.70 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.33

Arginine has been used by millions of athletes over the past 20 years to enhance production of human growth hormone.

Gene_expression (production) of growth hormone

9) Confidence 0.67 Published 2004 Journal Turk J Gastroenterol Section Abstract Doc Link 15264124 Disease Relevance 0.27 Pain Relevance 0.06

A disruption of the neuroendocrine axis controlling growth hormone production may be the link between disturbed sleep and muscle pain, as growth hormone is produced predominantly during stage four sleep.

Gene_expression (produced) of growth hormone in muscle associated with pain and myalgia

10) Confidence 0.64 Published 1993 Journal Rheum. Dis. Clin. North Am. Section Abstract Doc Link 7689237 Disease Relevance 0.61 Pain Relevance 0.22

With their many extraintestinal manifestations, they may masquerade as fever of unknown etiology, arthritis, anorexia nervosa, growth hormone deficiency, collagen-vascular disease, idiopathic growth retardation and even irritable bowel syndrome of childhood.

Gene_expression (deficiency) of growth hormone in bowel associated with spastic colon, increased venous pressure under development, growth hormone deficiency, fever, eating disorder and arthritis

11) Confidence 0.63 Published 1980 Journal Curr Probl Pediatr Section Abstract Doc Link 7379573 Disease Relevance 1.27 Pain Relevance 0.36

We investigated whether such exposure adversely affects estrous cyclicity and the expression and distribution of gonadotropin-releasing hormone (GnRH), GnRH receptors, and corticotrophin-releasing hormone (CRH) in the hypothalamus and whether the effects are mediated by the androgen receptor (AR).

Gene_expression (expression) of gonadotropin-releasing hormone in hypothalamus

12) Confidence 0.63 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2722078 Disease Relevance 0.48 Pain Relevance 0.22

In comparison with model group, hypothalamic GnRH mRNA, ovary GnRH mRNA, pituitary GnRH-R mRNA and uterus ER mRNA expressions in acupuncture and ELI groups were suppressed significantly (P<0.05), while uterus PR mRNA expressions in the later two groups were up-regulated obviously (P<0.05).

Gene_expression (expressions) of GnRH mRNA in uterus

13) Confidence 0.62 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0 Pain Relevance 0

Compared with control group, hypothalamic GnRH mRNA, ovary GnRH mRNA, pituitary GnRH-R mRNA and uterus ER mRNA expressions in model group were up-regulated significantly, while uterus PR mRNA was down-regulated markedly in model group (P<0.05).

Gene_expression (expressions) of GnRH-R in uterus

14) Confidence 0.61 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0 Pain Relevance 0

METHODS: Stainless steel tube was implanted into the 3rd cerebral ventricle and substance P (SP), C-terminal hexapeptide of Substance P (SP6-11), Gn-RH and adrenaline were infused on the 3rd day of the cycle (proestrus).

Gene_expression (infused) of Gn-RH in ventricle

15) Confidence 0.59 Published 1999 Journal Endocr Regul Section Body Doc Link 10700084 Disease Relevance 0 Pain Relevance 0

A disruption of the neuroendocrine axis controlling growth hormone production may be the link between disturbed sleep and muscle pain, as growth hormone is produced predominantly during stage four sleep.

Gene_expression (production) of growth hormone in muscle associated with pain and myalgia

16) Confidence 0.57 Published 1993 Journal Rheum. Dis. Clin. North Am. Section Abstract Doc Link 7689237 Disease Relevance 0.62 Pain Relevance 0.22

The serum levels of growth hormone and somatomedin-C spontaneously normalized seventeen days after this episode and have remained normal for two years.

Gene_expression (levels) of growth hormone

17) Confidence 0.57 Published 1996 Journal Intern. Med. Section Abstract Doc Link 8835599 Disease Relevance 0.79 Pain Relevance 0.10

By contrast, growth hormone levels in the naloxazone-treated animals were actually higher than in the naloxone-treated group.

Gene_expression (levels) of growth hormone associated with narcan

18) Confidence 0.57 Published 1982 Journal Life Sci. Section Abstract Doc Link 6298516 Disease Relevance 0 Pain Relevance 1.02

Growth hormone and prolactin levels during standardized exercise tests were measured in ten normal male volunteers, with and without previous intravenous administration of 4 mg naloxone.

Gene_expression (levels) of Growth hormone associated with narcan

19) Confidence 0.57 Published 1980 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 7226565 Disease Relevance 0 Pain Relevance 0.21

Compared with control group, hypothalamic GnRH mRNA, ovary GnRH mRNA, pituitary GnRH-R mRNA and uterus ER mRNA expressions in model group were up-regulated significantly, while uterus PR mRNA was down-regulated markedly in model group (P<0.05).

Gene_expression (expressions) of GnRH mRNA in uterus

20) Confidence 0.55 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19526799 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.