INT326044

Context Info Confidence 0.12 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.08 Pain Relevance 0.83

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67) intracellular (Mki67) molecular_function (Mki67) cellular_component (Mki67)

Mki67 (Rattus norvegicus)

Pain Link Frequency Relevance Heat fluoxetine 66 99.56 cytokine 8 23.56 sSRI 5 5.00 depression 5 5.00 antidepressant 5 5.00 Hippocampus 3 5.00 Serotonin 3 5.00 anesthesia 2 5.00 Versed 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Body Weight 2 78.72 Cirrhosis 1 32.56 Sepsis 1 19.72 Neurodegenerative Disease 19 5.00 Depression 5 5.00 Hypersensitivity 5 5.00 Targeted Disruption 4 5.00 Apoptosis 3 5.00 Exsanguination 2 5.00 Injury 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This effect is noted even before any "triggering" for regeneration took place, as rats pre-treated with rhEPO showed increased expression of both Ki 67 and PCNA before hepatectomy was performed.

Negative_regulation (showed) of Gene_expression (expression) of Ki 67

1) Confidence 0.12 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.08 Pain Relevance 0

In the second part of this experiment, as expected from Experiment 1, icv K252a for 14 days reduced Ki67 positive cells expression in 14-day fluoxetine -treated rats compared to those receiving fluoxetine and icv saline (One-way ANOVA: F (3,15) ?

Negative_regulation (reduced) of Gene_expression (expression) of Ki67 associated with fluoxetine

2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0 Pain Relevance 0.83

General Comments

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