INT326460

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0.18

nucleoplasm (NR1I2) signal transduction (NR1I2) oxidoreductase activity (Cyp4f18) endoplasmic reticulum (Cyp4f18) nucleus (NR1I2)

NR1I2 (Homo sapiens) Cyp4f18 (Mus musculus)

Pain Link Frequency Relevance Heat carbamazepine 2 93.76 antiepileptic Drug 6 92.84 anesthesia 2 21.40 anticonvulsant 2 5.00 iatrogenic 1 5.00

Disease Link Frequency Relevance Heat Fracture Healing 2 79.36 Convulsion 12 74.68 Osteoporosis 9 74.32 Injury 2 67.00 Dislocations 1 64.56 Hypocalcemia 1 64.16 Hypercalcemia 1 62.72 Compression Fractures 1 59.80 Humeral Fractures 1 54.20 Epilepsy 3 48.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pregnabe × receptor (PXR), a transcriptional regulator of CYP450, mediates the adverse effect on bone metabolism of both CYP450 inducers and inhibitors through stimulation of vitamin D catabolism and inhibition of 25-hydroxylation of vitamin D [16].

PXR Regulation (regulator) of CYP450

1) Confidence 0.01 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2919461 Disease Relevance 0.72 Pain Relevance 0.18

General Comments

This test has worked.