INT32660

Context Info Confidence 0.16 First Reported 1988 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 8 Total Number 9 Disease Relevance 2.30 Pain Relevance 1.21

pigmentation (Hps1) cytoplasmic membrane-bounded vesicle (Hps1)

Anatomy Link Frequency heart 2 cumulus cell 1 Hps1 (Mus musculus)

Pain Link Frequency Relevance Heat Hyperalgesia 4 99.76 Opioid 1 99.60 antagonist 5 99.32 Inflammation 20 98.96 narcan 7 98.88 Pain 24 98.68 Inflammatory mediators 3 97.32 IPN 6 96.40 agonist 14 89.28 qutenza 50 84.64

Disease Link Frequency Relevance Heat Hyperalgesia 19 99.76 Nociception 13 99.16 INFLAMMATION 25 98.96 Pain 19 98.68 Heart Rate Under Development 55 96.80 Inflammatory Pain 6 96.40 Arrhythmias 2 Under Development 105 93.32 Injury 3 91.88 Pressure And Volume Under Development 1 87.00 Targeted Disruption 1 83.68

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this review, Keith Bley, John Hunter, Richard Eglen and Jacqueline Smith compare the roles of EP and IP receptors in nociception and suggest that the IP receptor constitutes a novel target for anti-nociceptive agents.

Regulation (roles) of EP associated with nociception

1) Confidence 0.16 Published 1998 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 9612089 Disease Relevance 0.95 Pain Relevance 0.46

The effects of the pro-opiomelanocortin-derived beta-endorphin (B-EP) and the opioid antagonist naloxone on in vitro secretion (accumulation of testosterone (T) in the medium) of T by testicular cells were assessed in adult white-footed mice (Peromyscus leucopus).

Regulation (effects) of B-EP associated with antagonist, narcan and opioid

2) Confidence 0.06 Published 1988 Journal Biol. Reprod. Section Abstract Doc Link 2974731 Disease Relevance 0 Pain Relevance 0.30

The role of their receptors (EP and IP, respectively) in inflammation has been well documented, although the EP receptor subtypes involved in this process and the underlying cellular mechanisms remain to be elucidated.

Regulation (role) of EP associated with inflammation

3) Confidence 0.05 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1074353 Disease Relevance 0.54 Pain Relevance 0.45

Further analysis of ECG signals recorded during electrochemotherapy was performed to estimate the effect of EP pulse delivery on ECG.

Regulation (effect) of EP

4) Confidence 0.04 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2491703 Disease Relevance 0 Pain Relevance 0

For evaluation of the effects of EP pulse delivery on functioning of the heart we calculated the average values of RR interval, QRS interval, QTc interval, QRS area and R wave amplitude before and after the application of EP pulses.

Regulation (effects) of EP in heart

5) Confidence 0.04 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2491703 Disease Relevance 0 Pain Relevance 0

The main purpose of this study was therefore to investigate the possible effects of EP pulses on functioning of the heart and to address the relevance of synchronization of EP pulse delivery with ECG.

Spec (possible) Regulation (effects) of EP in heart

6) Confidence 0.04 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2491703 Disease Relevance 0.57 Pain Relevance 0

Based on these scores and in the absence of any standard performance metrics for EP pulse delivery, we calculated the performance measures analogous to QRS detection metrics: the sensitivity (Sep), the positive predictivity (+Pp) and the delivery error rate (DERp) for EP pulses.

Regulation (sensitivity) of EP

7) Confidence 0.04 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2491703 Disease Relevance 0.13 Pain Relevance 0

The performance of our algorithm for QRS detection and EP pulse delivery has previously been evaluated on ECG signals from a standard LTST DB database [30].

Regulation (algorithm) of EP

8) Confidence 0.04 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2491703 Disease Relevance 0.11 Pain Relevance 0

It is possible that cumulus cell expression of EP receptors changes in response to the midcycle LH surge, which may explain discrepancies between these studies.

Spec (possible) Regulation (changes) of EP in cumulus cell

9) Confidence 0.04 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0

General Comments

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