INT326661

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.96 Pain Relevance 0.86

endosome (Arc) extracellular region (Bdnf) plasma membrane (Arc) cytoskeleton (Arc) cytoplasmic membrane-bounded vesicle (Bdnf) cytoskeleton organization (Arc)

Anatomy Link Frequency neurons 2 Bdnf (Mus musculus) Arc (Mus musculus)

Pain Link Frequency Relevance Heat bDMF 36 100.00 intrathecal 20 99.92 Dorsal horn neuron 12 99.20 Spinal cord 50 90.48 GABAergic 10 82.20 allodynia 4 39.08 Thermal hyperalgesia 2 38.52 Neuropathic pain 8 36.48 Lasting pain 14 11.92 Dorsal horn 24 9.68

Disease Link Frequency Relevance Heat Aids-related Complex 262 100.00 Nociception 82 50.00 Nervous System Injury 12 43.76 Neuropathic Pain 14 39.08 Hyperalgesia 6 38.52 Pain 56 11.92 Targeted Disruption 68 5.04 Depression 14 5.00 INFLAMMATION 10 5.00 Inflammatory Pain 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Intrathecal injection of BDNF induces Arc/Arg3.1 mRNA expression

BDNF Positive_regulation (induces) of Gene_expression (expression) of Arc/Arg3.1 mRNA associated with aids-related complex, bdmf and intrathecal

1) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.97 Pain Relevance 0.43

Intrathecal injection of brain-derived neurotrophic factor (BDNF) induced Arc/Arg3.1 mRNA expression in the superficial dorsal horn neurons (10 ± 1.7/section, n = 6).

brain-derived neurotrophic factor Positive_regulation (induced) of Gene_expression (expression) of Arc/Arg3.1 mRNA in neurons associated with aids-related complex, dorsal horn neuron, bdmf and intrathecal

2) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.99 Pain Relevance 0.43

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