INT327179

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.03
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mpl)
Anatomy Link Frequency
brain 3
astrocytes 1
Mpl (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 70 99.68 Very High Very High Very High
Hippocampus 45 84.16 Quite High
Inflammatory response 5 80.64 Quite High
cerebral cortex 35 74.64 Quite High
Thalamus 25 72.08 Quite High
medulla 40 63.60 Quite High
ischemia 5 62.88 Quite High
Spinal cord 40 58.72 Quite High
midbrain 20 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 20 98.68 Very High Very High Very High
Congenital Anomalies 40 83.72 Quite High
Meningitis 5 82.72 Quite High
INFLAMMATION 5 80.28 Quite High
Cv Unclassified Under Development 5 62.88 Quite High
Cerebral Hypoxia 5 62.52 Quite High
Apoptosis 20 58.96 Quite High
Syndrome 20 51.84 Quite High
Thrombocytopenia 30 51.20 Quite High
Targeted Disruption 20 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It becomes evident that the Mpl is developmentally regulated, since Mpl is not detectable on protein levels at the very early stages (E12 and E15) of brain development (Figure 2A-C).
Regulation (regulated) of Mpl in brain
1) Confidence 0.62 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.08 Pain Relevance 0.03
To further elucidate the role of the Thpo/Mpl system in the brain, we analysed herein the expression pattern of the Mpl protein in the murine brain by immunohistochemistry.
Regulation (role) of Mpl in brain
2) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.08 Pain Relevance 0.03
However, data on the expression and regulation of Mpl in the CNS are very limited.
Regulation (regulation) of Mpl associated with central nervous system
3) Confidence 0.27 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.52 Pain Relevance 0.32
This may be important for future dissection of the regulation and function of the Thpo/Mpl system in the brain.
Regulation (regulation) of Mpl in brain
4) Confidence 0.27 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.14
The hypoxic up-regulation of Mpl expression in astrocytes contrasts the down-regulation of the Mpl in neuronal cells under the same conditions [3], raising the question whether the Thpo/Mpl system exhibits a different role in astrocytes vs. neurons.
Regulation (regulation) of Mpl in astrocytes associated with hypoxia
5) Confidence 0.24 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.35 Pain Relevance 0

General Comments

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