INT327328

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.74 Pain Relevance 0.30

RNA binding (Hnrnpd, Elavl1) nucleus (Hnrnpd, Elavl1) cytoplasm (Hnrnpd, Elavl1) cytosol (Hnrnpd) DNA binding (Hnrnpd)

Hnrnpd (Mus musculus) Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory stimuli 6 93.68 Inflammation 232 81.20 cytokine 66 80.16 chemokine 20 5.00 cINOD 10 5.00 Arthritis 10 5.00 Inflammatory response 8 5.00 Kinase C 8 5.00 aspirin 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 240 93.36 Cancer 288 90.60 Targeted Disruption 12 20.88 Bacterial Infection 2 17.52 Hypoxia 22 5.00 Metastasis 18 5.00 Disease 18 5.00 Colon Cancer 16 5.00 Colitis 12 5.00 Hyperplasia 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A specific example is that siRNA-mediated knockdown of HuR led to larger AUF1 association with cyclin D and p21 mRNAs [80].

AUF1 Binding (association) of HuR

1) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.38 Pain Relevance 0.16

Associations of KSRP and AUF1 p45, or KSRP and HuR, allow fine tuning of ARE-mRNA stability [93, 94].

AUF1 p45 Binding (Associations) of HuR

2) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.36 Pain Relevance 0.14

General Comments

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