INT327779

Context Info Confidence 0.48 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 4.50 Pain Relevance 0.60

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4) cytoplasm (AQP4)

Anatomy Link Frequency muscles 4 plasma 2 glial cells 2 brain 2 AQP4 (Homo sapiens)

Pain Link Frequency Relevance Heat Dopamine 32 98.16 Inflammation 26 91.20 ischemia 8 88.76 Neurotransmitter 8 83.60 Neuritis 26 81.32 Central nervous system 4 61.76 Spinal cord 41 60.12 Substantia nigra 8 48.48 Multiple sclerosis 32 42.80 potassium channel 12 32.08

Disease Link Frequency Relevance Heat Atrophy 28 99.88 Motor Neuron Diseases 76 99.42 Neuromyelitis Optica 252 99.04 Targeted Disruption 45 99.00 INFLAMMATION 26 91.20 Stroke 4 89.16 Cv Unclassified Under Development 8 88.76 Pressure And Volume Under Development 1 83.60 Disease 290 82.52 Neurodegenerative Disease 52 82.08

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Anatomy

Negation

Speculation

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The results presented by these authors show a down-regulation of AQP4 expression in striatal glial cells in vitro mediated by DA.

Regulation (regulation) of Gene_expression (expression) of AQP4 in glial cells associated with dopamine

1) Confidence 0.48 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.37 Pain Relevance 0.25

ALS), there has been a very few data on the expression of AQP4; in human muscles with neurogenic atrophy, the expression of AQP4 was down-regulated.

Regulation (regulated) of Gene_expression (expression) of AQP4 in muscles associated with atrophy and motor neuron diseases

2) Confidence 0.35 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.20 Pain Relevance 0.03

ALS), there has been a very few data on the expression of AQP4; in human muscles with neurogenic atrophy, the expression of AQP4 was down-regulated.

Regulation (data) of Gene_expression (expression) of AQP4 in muscles associated with atrophy and motor neuron diseases

3) Confidence 0.35 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.31 Pain Relevance 0.03

A number of recent in vitro and in vivo studies revealed that IgG from patients with NMO initiates endocytosis of AQP4, a process which alters the polarized expression pattern of AQP4 on the plasma membrane and, as a functional consequence, increases BBB permeability in vitro [35-37].

Regulation (alters) of Gene_expression (expression) of AQP4 in plasma associated with neuromyelitis optica

4) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 0.76 Pain Relevance 0.24

The modified AQP4 expression patterns were especially intriguing: changes observed in the expression of ion and water channels could explain the differences in the mobility of water and ions into and out of brain cells and in BBB integrity.

Regulation (modified) of Gene_expression (expression) of AQP4 in brain

5) Confidence 0.21 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.85 Pain Relevance 0.04

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