INT327791

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.10 Pain Relevance 0.17

cytoplasm (AQP4, Alms1) transport (AQP4) cilium (Alms1) lipid metabolic process (Alms1) transmembrane transport (AQP4) plasma membrane (AQP4)

AQP4 (Homo sapiens) Alms1 (Mus musculus)

Pain Link Frequency Relevance Heat Demyelination 4 79.36 Spinal cord 10 66.08 cytokine 2 47.52 Multiple sclerosis 6 43.72 addiction 3 34.52 ischemia 2 32.88 Dopamine 8 5.00 Inflammation 5 5.00 potassium channel 3 5.00 Neuritis 3 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 57 100.00 Necrosis 2 92.32 Demyelinating Disease 14 79.36 Hyalinosis 1 63.32 Hyperplasia 1 62.56 Edema 3 40.88 Cv Unclassified Under Development 2 32.88 Disease 69 7.68 Motor Neuron Diseases 19 5.00 Neurodegenerative Disease 13 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The limited access of circulating IgG to the extracapillary space in the CNS would only permit interaction of NMO-IgG with AQP4 at the glia limitans of BBB: in consequence of these findings, many authors suggest the perivascular space as the primary target site of the pathogenic process.

AQP4 Binding (interaction) of BBB associated with neuromyelitis optica

1) Confidence 0.03 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.10 Pain Relevance 0.17

General Comments

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